Age-Dependent Acquisition of Protective Immunity to Malaria in Riverine Populations of the Amazon Basin of Brazil

dc.creatorAndrade, Simone Ladeia
dc.creatorFerreira, Marcelo Urbano
dc.creatorCarvalho, Maria Esther de
dc.creatorCurado, Izilda
dc.creatorCoura, José Rodrigues
dc.date2019-01-17T13:05:24Z
dc.date2019-01-17T13:05:24Z
dc.date2009
dc.date.accessioned2023-09-26T20:30:14Z
dc.date.available2023-09-26T20:30:14Z
dc.identifierANDRADE, Simone Ladeia; et al. Age-Dependent Acquisition of Protective Immunity to Malaria in Riverine Populations of the Amazon Basin of Brazil. Am. J. Trop. Med. Hyg., v. 80, n. 3, p. 452–459, 2009.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31104
dc.identifier1476-1645
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858331
dc.descriptionFive community-based cross-sectional surveys of malaria morbidity and associated risk factors in remote riverine populations in northwestern Brazil showed average parasite rates of 4.2% (thick-smear microscopy) and 14.4% (polymerase chain reaction [PCR]) in the overall population, with a spleen rate of 13.9% among children 2–9 years of age. Plasmodium vivax was 2.8 times more prevalent than P. falciparum , with rare instances of P. malariae and mixed-species infections confirmed by PCR; 9.6% of asymptomatic subjects had parasitemias detected by PCR. Low-grade parasitemia detected by PCR only was a risk factor for anemia, after controlling for age and other covariates. Although clinical and subclinical infections occurred in all age groups, the risk of infection and disease decreased significantly with increasing age, after adjustment for several covariates in multilevel logistic regression models. These findings suggest that the continuous exposure to hypo- or mesoendemic malaria may induce significant anti-parasite and anti-disease immunity in native Amazonians.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectMalária
dc.subjectBacia Amazônica
dc.subjectBrasil
dc.subjectImunidade
dc.subjectPopulações ribeirinhas
dc.subjectMalaria
dc.subjectProtective Immunity
dc.subjectRiverine Populations
dc.subjectAmazon Basin of Brazil
dc.titleAge-Dependent Acquisition of Protective Immunity to Malaria in Riverine Populations of the Amazon Basin of Brazil
dc.typeArticle


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