Pirahy virus: identification of a new and potential emerging arbovirus in South Brazil

dc.creatorTschá, Marcel Kruchelski
dc.creatorSuzukawa, Andréia Akemi
dc.creatorRodrigues-Luiz, Gabriela Flavia
dc.creatorSilva, Allan Martins da
dc.creatorCataneo, Allan Henrique Depieri
dc.creatorCoelho, Gabriela Mattoso
dc.creatorFerreira, Adão Celestino
dc.creatorMedeiros, Lia Carolina Soares
dc.creatorMansur, Daniel
dc.creatorZanluca, Camila
dc.creatorSantos, Claudia Nunes Duarte dos
dc.date2022-05-10T19:46:30Z
dc.date2022-05-10T19:46:30Z
dc.date2022
dc.date.accessioned2023-09-26T20:29:59Z
dc.date.available2023-09-26T20:29:59Z
dc.identifierTSCHÁ, Marcel Kruchelski et al. Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil. Virus Evolution, v. 7, n. 2, p. 1–14, 2022.
dc.identifier2057-1577
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/52604
dc.identifier10.1093/ve/veab105
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858242
dc.descriptionGenomic and epidemiological surveillance are paramount for the discovery of new viruses with the potential to cross species barriers. Here, we present a new member of the genus Alphavirus found in Trichoprosopon and Wyeomia mosquitoes, tentatively named Pirahy virus (PIRAV). PIRAV was isolated from mosquito pools collected in a rural area of Piraí do Sul, South Brazil. In vitro assays revealed that PIRAV replicates and causes cytopathic effects in vertebrate cell lines such as Vero E6, SH-SY5Y, BHK-21 and UMNSAH/DF-1. Genomic signature analysis supports these results showing a dinucleotide and codon usage balance compatible with several hosts. Phylogenetic analyses placed PIRAV basal to the Venezuelan equine encephalitis complex. Genome analyses, electron microscopy, and biological characterization show findings that may alert for the emergence of a new arbovirus in South America.
dc.formatapplication/pdf
dc.languagepor
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectAlphavirus
dc.subjectTrichoprosopon
dc.subjectWyeomyia
dc.subjectEncefalite Equina Venezuelana
dc.subjectArboviruses
dc.subjectPhylogeny
dc.subjectCodon
dc.subjectDinucleotide Repeats
dc.subjectEncephalomyelitis, Venezuelan Equine
dc.subjectArbovirus
dc.subjectFilogenia
dc.subjectRepeticiones de Dinucleótido
dc.subjectEncefalomielitis Equina Venezolana
dc.subjectPhylogenèse
dc.subjectRépétitions de dinucléotides
dc.subjectEncéphalomyélite équine du Vénézuéla
dc.subjectArbovírus
dc.subjectFilogenia
dc.subjectCódon
dc.subjectRepetições de Dinucleotídeos
dc.subjectCulicidae
dc.titlePirahy virus: identification of a new and potential emerging arbovirus in South Brazil
dc.typeArticle


Este ítem pertenece a la siguiente institución