Chronic Chagas' disease in rhesus monkeys (Macaca mulatta): evaluation of parasitemia, serology, electrocardiography, echocardiography, and radiology

dc.creatorCarvalho, C. M. E.
dc.creatorAndrade, M. C. R.
dc.creatorXavier, S. S.
dc.creatorMangia, R. H. R.
dc.creatorBritto, C. C.
dc.creatorJansen, A. M.
dc.creatorFernandes, O.
dc.creatorVieira, J. L.
dc.creatorAlmeida, M. D. B.
dc.date2019-05-23T14:19:49Z
dc.date2019-05-23T14:19:49Z
dc.date2003
dc.date.accessioned2023-09-26T20:28:59Z
dc.date.available2023-09-26T20:28:59Z
dc.identifierCARVALHO, Cristiano Marcelo Espinola et al. Chronic Chagas' disease in rhesus monkeys (Macaca mulatta): evaluation of parasitemia, serology, electrocardiography, echocardiography, and radiology. American Journal of Tropical Medicine and Hygiene, v. 68, n. 6, p. 683-691, 2003.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33195
dc.identifier1476-1645
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857886
dc.descriptionSevere chronic damage to the heart and gastrointestinal tract in patients with Chagas’ disease are often observed 10-20 years after the acute phase. The course of long-lasting infection with the Colombian strain of Trypanosoma cruzi was studied in seven rhesus monkeys infected for 15–19 years. Subpatent parasitemia was detected in all studied animals, using hemoculture (two of seven), artificial xenodiagnosis (three of seven), and a polymerase chain reaction PCR (six of six). High titers of specific IgG antibody to T. cruzi persisted throughout the chronic phase of infection. Abnormal electrocardiographic (three of six) and echocardiographic (one of six) patterns detected in the T. cruzi-infected monkeys were possibly related to parasite-triggered myocardial damage. The results suggest that rhesus monkeys experimentally infected with T. cruzi, besides reproducing the acute phase of Chagas’ disease, also develop chronic chagasic cardiomyopathy.
dc.description2020-05-23
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectChagas' disease
dc.subjectRhesus monkeys
dc.subjectParasitemia
dc.subjectSerology
dc.subjectElectrocardiography
dc.subjectEchocardiography
dc.subjectRadiology
dc.titleChronic Chagas' disease in rhesus monkeys (Macaca mulatta): evaluation of parasitemia, serology, electrocardiography, echocardiography, and radiology
dc.typeArticle


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