Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.

dc.creatorVidal, Maura R. F. S
dc.creatorBarbosa Junior, Aryon de Almeida
dc.creatorAndrade, Zilton de Araújo
dc.date2012-10-30T20:32:24Z
dc.date2012-10-30T20:32:24Z
dc.date1993
dc.date.accessioned2023-09-26T20:28:31Z
dc.date.available2023-09-26T20:28:31Z
dc.identifierVIDAL, M. R. S.; BARBOSA JÚNIOR, A. A.; ANDRADE, Z. A. Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas. Revista do Instituto de Medicina Tropical de São Paulo, v. 35, n. 5, p. 423-9, sep.-oct. 1993.
dc.identifier0036-4665
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5744
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857718
dc.descriptionNumerous pulmonary schistosome egg granulomas were present in mice submitted to partial portal vein ligation (Warren's model). The granulomas were characterized by cellular aggregations formed within alveolar tissue. Main cellular types were macrophages (epithelioid cells), eosinophils, plasma cells and lymphocytes. These cells were supported by scanty fibrous stroma and exhibited close membrane contact points amongst themselves, but without forming specialized adhesion apparatus. When granulomas involved arterial structures, proliferation of endothelial and smooth muscle cells occurred and fibrosis associated with angiogenesis became more evident. Granulomas formed around mature eggs in the pulmonary alveolar tissue presented approximately the same size and morphology regardless of the time of infection, the latter being 10, 18 and 25 weeks after cercarial exposure. This persistence of morphological appearance suggests that pulmonary granulomas do not undergo immunological modulation, as is the case with the granulomas in the liver and, to a lesser extent, in the intestines. Probably, besides general immunological factors, local (stromal) factors play an important role in schistosomal granuloma modulation.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectExperimental schistosomiasis
dc.subjectPulmonary schistosomiasis
dc.subjectPeriovular granuloma
dc.subjectImmunological modulation
dc.subjectGranuloma/patologia
dc.subjectPneumopatias Parasitárias/patologia
dc.subjectEsquistossomose/patologia
dc.subjectAnimais
dc.subjectGranuloma/parasitologia
dc.subjectPulmão/parasitologia
dc.subjectPulmão/ultraestrutura
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectÓvulo/parasitologia
dc.subjectVeia Porta/cirurgia
dc.subjectFatores de Tempo
dc.titleExperimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
dc.typeArticle


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