Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis

dc.creatorMorgado, F. N.
dc.creatorCarvalho, L. M. V. de
dc.creatorSilva, J. Leite
dc.creatorSeba, A. J.
dc.creatorPimentel, M. I. F.
dc.creatorFagundes, A.
dc.creatorMadeira, M. F.
dc.creatorLyra, M. R.
dc.creatorOliveira, M. M.
dc.creatorSchubach, A. O.
dc.creatorSilva, F. Conceição
dc.date2018-10-03T13:49:32Z
dc.date2018-10-03T13:49:32Z
dc.date2018
dc.date.accessioned2023-09-26T20:27:29Z
dc.date.available2023-09-26T20:27:29Z
dc.identifierMORGADO, F. N. et al. Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis. Scientific Reports, v. 8, n. 2898, p. 1-10, Feb. 2018.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29257
dc.identifier10.1038/s41598-018-21277-1
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857345
dc.descriptionThe clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. In contrast, LC-SP had a substantially higher percentage of CD4, BCl2 and neutrophils than ATL lesions. These results indicated some differences in the profile of the in situ immune response suggesting that SIS is a complex, adaptable system capable of different responses to intracellular or extracellular pathogens. However, regardless of the etiological agents, the inflammatory reaction and clinical manifestations can be similar. SCL-ATL and LC-SP presented similarities in both clinical presentation and in situ inflammatory profile (CD3, CD22, neutrophils, macrophages). The clinical presentation of ATL and sporotrichosis could be explained by a combination of factors both of the host SIS and the etiological agent. The unbalanced host parasite relationship could result in atypical manifestations of skin disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Research
dc.rightsopen access
dc.subjectDoenças infecciosas cutâneas
dc.subjectInflamação
dc.subjectLeishmaniose
dc.subjectEsporotricose
dc.subjectDestruição tecidual
dc.subjectEstudo comparativo
dc.subjectSporotrichosis
dc.subjectLeishmaniasis
dc.subjectInflammation
dc.subjectTissue destruction
dc.subjectSkin infectious diseases
dc.subjectComparative study
dc.titleUnbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis
dc.typeArticle


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