Cytotoxic cell involvement in human cutaneous leishmaniasis: assessments in active disease, under therapy and after clinical cure

dc.creatorCunha, C. F.
dc.creatorFerraz, R.
dc.creatorPimentel, M. I. F.
dc.creatorLyra, M. R.
dc.creatorSchubach, A. O.
dc.creatorCruz, A. M. da
dc.creatorBertho, A. L.
dc.date2016-12-08T11:51:34Z
dc.date2016-12-08T11:51:34Z
dc.date2016
dc.date.accessioned2023-09-26T20:27:27Z
dc.date.available2023-09-26T20:27:27Z
dc.identifierCUNHA, C. F. et al. Cytotoxic cell involvement in human cutaneous leishmaniasis: assessments in active disease, under therapy and after clinical cure. Parasite Immunology, n.38, p.244-254, 2016.
dc.identifier0141-9838
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16481
dc.identifier10.1111/pim.12312
dc.identifier1365-3024
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857334
dc.descriptionCutaneous leishmaniasis (CL) is an important public health issue worldwide. The control of Leishmania infection depends on cellular immune mechanisms, and the inflammatory response may contribute to pathogenesis. A beneficial role of CD8(+) T lymphocytes has been proposed; nevertheless, other studies suggest a cytotoxic role of CD8(+) T lymphocytes involved in tissue damage, showing controversial role of these cells. The goal of the current study was to understand the immunopathology of CL and determine the profile of cytotoxic cells--such as CD4(+) T, natural killer and natural killer T cells--that might be involved in triggering immunological mechanisms, and may lead to cure or disease progression. The frequencies of cytotoxic cell populations in peripheral blood, obtained from patients with active disease, during treatment and after clinical healing, were assessed by flow cytometry. Cytotoxicity could not be related to a deleterious role in Leishmania braziliensis infection, as patients with active CL showed similar percentages of degranulation to healthy individuals (HI). Cured patients exhibited a lower percentage of degranulating cells, which may be due to a downregulation of the immune response. The understanding of the immunopathological mechanisms involved in CL and the commitment of cytotoxic cells enables improvements in therapeutic strategies.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectCitometria de fluxo
dc.subjectCélulas Matadoras Naturais
dc.subjectLeishmaniose
dc.subjectLeishmaniose Cutânea
dc.subjectCD107a
dc.subjectcytotoxic T cells
dc.subjectflow cytometry
dc.subjecthuman cutaneous leishmaniasis
dc.subjectNK cells
dc.subjectNKT cells
dc.titleCytotoxic cell involvement in human cutaneous leishmaniasis: assessments in active disease, under therapy and after clinical cure
dc.typeArticle


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