Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies

dc.creatorCarvalho, Eduardo C. Nascimento
dc.creatorVasconcellos, Ângela G.
dc.creatorClarêncio, Jorge
dc.creatorAndrade, Daniela
dc.creatorBarral, Aldina Maria Prado
dc.creatorBarral Netto, Manoel
dc.creatorCarvalho, Cristiana Maria Nascimento
dc.date2019-10-31T16:55:50Z
dc.date2019-10-31T16:55:50Z
dc.date2019
dc.date.accessioned2023-09-26T20:27:19Z
dc.date.available2023-09-26T20:27:19Z
dc.identifierCARVALHO, Eduardo C. Nascimento et al. Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies. Pediatric Pulmonology, p. 1-8, 2019.
dc.identifier8755-6863
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36785
dc.identifier10.1002/ppul.24533
dc.identifier1099-0496
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857284
dc.descriptionBahia State Agency for Research Funding, Grant/Award Number: PNX 0019/2009.
dc.descriptionAim: To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community‐acquired pneumonia (CAP) with and without pneumococcal infection. Methods: Children less than 5‐years‐old hospitalized with CAP were prospectively investigated in Salvador, Brazil. Clinical data and biological samples were collected to investigate 20 etiological agents and to determine serum cytokines/chemokines levels on admission and 2 to 4 weeks later. Cases with pneumococcal infection received this diagnosis irrespective of also having other etiologies. Results: A total of 277 patients were enrolled, however, serum sample was unavailable for cytokine measurement upon admission (n = 61) or upon follow‐up visit (n = 36), etiology was undetected (n = 50) and one patient did not attend the follow‐up visit. Therefore, this study group comprised of 129 cases with established etiology. The median (interquartile range) age and sampling interval was 18 (9‐27) months and 18 (16‐21) days, respectively. Established etiology was viral (52.0%), viral‐bacterial (30.2%), and bacterial (17.8%). Pneumococcal infection was found in 31 (24.0%) patients. Overall, median interleukin‐6 (IL‐6; 10.6 [4.7‐30.6] vs 21.0 [20.2‐21.7]; P = .03), IL‐10 (3.5 [3.1‐4.5] vs 20.1 [19.8‐20.4]; P < .001), and CCL2 (19.3 [12.4‐23.2] vs 94.0 [67.2‐117.8]; P < .001) were significantly higher in convalescent serum samples, whereas median CXCL10 (83.6 [36.4‐182.9] vs 14.6 [0‐116.6]; P < .001) was lower. Acute vs convalescent levels evolution of IL‐10, CCL2, and CXCL10 did not differ among patients with or without pneumococcal infection. However, IL‐6 decreased (27.8 [12.3‐48.6] vs 20.8 [20.2‐22.6]; P = .1) in patients with pneumococcal infection and increased (9.0 [4.2‐22.6] vs 21.0 [20.2‐21.7]; P = .001) in patients without it. Conclusion: The marked increase of IL‐6 serum levels during the acute phase makes it a potential biomarker of pneumococcal infection among children with CAP.
dc.description2020-01-08
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectInfecção respiratória aguda
dc.subjectCriança
dc.subjectInfecção do trato respiratório inferior
dc.subjectDoença pulmonar
dc.subjectInfecção Pneumocócica
dc.subjectAcute respiratory infection
dc.subjectChild
dc.subjectLower respiratory tract infection
dc.subjectLung disease
dc.subjectPneumococcal infection
dc.titleEvolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies
dc.typeArticle


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