Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction

dc.creatorTemporal, R. M.
dc.creatorCysne-Finkelstein, L.
dc.creatorEchevarria, A.
dc.creatorGonçalves, A. J. Silva
dc.creatorLeon, L. L.
dc.creatorGenestra, M. S.
dc.date2019-12-17T11:27:26Z
dc.date2019-12-17T11:27:26Z
dc.date2005
dc.date.accessioned2023-09-26T20:27:17Z
dc.date.available2023-09-26T20:27:17Z
dc.identifierTEMPORAL, R. M. et al. Amidine Derivatives and Leishmania amazonensis: an Evaluation of the Effect of Nitric Oxide (NO) Production on the Parasite-macrophage Interaction. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 20, n. 1, p. 13-18, Feb. 2005.
dc.identifier1475-6366
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38022
dc.identifier10.1080/14756360400015207
dc.identifier1475-6374
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857272
dc.descriptionPrevious work has demonstrated that N-N'-diphenyl-R-benzamidine was highly effective against Leishmania amazonensis promastigotes/axenic amastigotes and Trypanosoma evansi trypomastigotes and the compound with a methoxy substituent, was the most effective derivative in the parasite-macrophage interaction. Comparative analysis of the nitric oxide (NO) released from the culture infection's supernatant showed the amidine to be less effective than pentamidine Isethionate as a reference drug. Additionally, in order to verify if the methoxylated derivative interferes with NO production by L. amazonensis, the effect of the amidine on the constitutive nitric oxide synthase (cNOS) purified from parasites, was examined, but demonstrated less activity in comparison with the reference drug. This data contributes to studies concerning the metabolic targets present in Leishmania parasites for leishmanicidal drugs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsopen access
dc.subjectLeishmania amazonensis
dc.subjectÓxido Nítrico
dc.subjectÓxido Nítrico Sintase
dc.subjectPentamidina
dc.subjectAmidina
dc.subjectLeishmania amazonensis
dc.subjectNitric oxide
dc.subjectNitric oxide synthase
dc.subjectPentamidine
dc.subjectMethoxy-amidine
dc.titleAmidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
dc.typeArticle


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