Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study

dc.creatorMaruza, Magda
dc.creatorAlbuquerque, Maria F. P. Militão
dc.creatorCoimbra, Isabella
dc.creatorMoura, Líbia V.
dc.creatorMontarroyos, Ulisses R.
dc.creatorMiranda Filho, Demócrito B.
dc.creatorLacerda, Heloísa R.
dc.creatorRodrigues, Laura C.
dc.creatorXimenes, Ricardo A. A.
dc.date2018-09-05T12:15:05Z
dc.date2018-09-05T12:15:05Z
dc.date2011
dc.date.accessioned2023-09-26T20:27:03Z
dc.date.available2023-09-26T20:27:03Z
dc.identifierMARUZA, M. et al. Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study. BMC infectious diseases, v. 11, p. 351, 16 dez. 2011.
dc.identifier1471-2334
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28564
dc.identifier10.1186/1471-2334-11-351
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857184
dc.descriptionMinistério da Saúde do Brasil / Programa DST / AIDS / UNESCO (CSV 182/06 - Projeto "Estudo Clínico-Epidemiológico da Co-Infecção HIV / Tuberculose em Recife"). Os autores foram parcialmente apoiados pelo CNPq (bolsa 308311 / 2009-4 para RAAX e bolsa 301779 / 2009-0 para MFPMA e bolsa 310911 / 2009-5 para HRL).
dc.descriptionBACKGROUND: Concomitant treatment of Human Immunodeficiency Virus (HIV) infection and tuberculosis (TB) presents a series of challenges for treatment compliance for both providers and patients. We carried out this study to identify risk factors for default from TB treatment in people living with HIV. METHODS: We conducted a cohort study to monitor HIV/TB co-infected subjects in Pernambuco, Brazil, on a monthly basis, until completion or default of treatment for TB. Logistic regression was used to calculate crude and adjusted odds ratios, 95% confidence intervals and P-values. RESULTS: From a cohort of 2310 HIV subjects, 390 individuals (16.9%) who had started treatment after a diagnosis of TB were selected, and data on 273 individuals who completed or defaulted on treatment for TB were analyzed. The default rate was 21.7% and the following risk factors were identified: male gender, smoking and CD4 T-cell count less than 200 cells/mm3. Age over 29 years, complete or incomplete secondary or university education and the use of highly active antiretroviral therapy (HAART) were identified as protective factors for the outcome. CONCLUSION: The results point to the need for more specific actions, aiming to reduce the default from TB treatment in males, younger adults with low education, smokers and people with CD4 T-cell counts < 200 cells/mm3. Default was less likely to occur in patients under HAART, reinforcing the strategy of early initiation of HAART in individuals with TB.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectVírus da imunodeficiência humana
dc.subjectPaciente com Vírus da Imunodeficiência Humana
dc.subjectTerapia de observação direta
dc.subjectModelo Multivariado Final
dc.subjectPadrão de tratamento
dc.subjectHuman Immunodeficiency Virus
dc.subjectHuman Immunodeficiency Virus Patient
dc.subjectDirectly Observe Therapy
dc.subjectFinal Multivariate Model
dc.subjectTreatment Default
dc.subjectInfecções Oportunistas Relacionadas com a AIDS / quimioterapia
dc.subjectInfecções Oportunistas Relacionadas com a AIDS / epidemiologia
dc.subjectTerapia Antirretroviral de Alta Atividade
dc.subjectBrasil
dc.subjectContagem de linfócitos CD4
dc.subjectStatus educacional
dc.subjectInfecções por HIV / complicações
dc.subjectInfecções por HIV / quimioterapia
dc.subjectConformidade do paciente
dc.subjectEstudos Prospectivos
dc.subjectFatores de Risco
dc.subjectFatores Sexuais
dc.subjectTuberculose / complicações
dc.subjectTuberculose / quimioterapia
dc.subjectTuberculose / epidemiologia
dc.subjectAdulto jovem
dc.subjectFumar
dc.subjectInfecções por HIV / epidemiologia
dc.titleRisk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study
dc.typeArticle


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