Interspecies and Intrastrain Interplay among Leishmania spp. Parasites

dc.creatorChagas, Bruna Dias das
dc.creatorPereira, Thaís Martins
dc.creatorCantanhêde, Lilian Mota
dc.creatorSilva, Gabriela Pereira da
dc.creatorBoité, Mariana Côrtes
dc.creatorPereira, Luiza de Oliveira Ramos
dc.creatorCupollilo, Elisa
dc.date2022-10-04T21:01:45Z
dc.date2022-10-04T21:01:45Z
dc.date2022
dc.date.accessioned2023-09-26T20:26:58Z
dc.date.available2023-09-26T20:26:58Z
dc.identifierCHAGAS, Bruna Dias das et al. Interspecies and Intrastrain Interplay among Leishmania spp. Parasites. Microorganisms, v. 10, 1883, p. 1 - 21, Sept. 2022.
dc.identifier2076-2607
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54994
dc.identifier10.3390/ microorganisms10101883
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857151
dc.descriptionLeishmania parasites present astonishing adaptative abilities that represent a matter of life or death within disparate environments during the heteroxenous parasite life cycle. From an evolutionary perspective, organisms develop methods of overcoming such challenges. Strategies that extend beyond the genetic diversity have been discussed and include variability between parasite cells during the infections of their hosts. The occurrence of Leishmania subpopulation fluctuations with variable structural genomic contents demonstrates that a single strain might shelter the variability required to overcome inconsistent environments. Such intrastrain variability provides parasites with an extraordinary ability to adapt and thus survive and propagate. However, different perspectives on this evolution have been proposed. Strains or species living in the same environment can cooperate but also compete. These interactions might increase the replication rate of some parasites but cause the loss of more aggressive competitors for others. Adaptive responses to intra- and interspecific competition can evolve as a fixed strategy (replication is adapted to the average genetic complexity of infections) or an optional strategy (replication varies according to the genetic complexity of the current infection). This review highlights the complexity of interspecies and intrastrain interactions among Leishmania parasites as well as the different factors that influence this interplay.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectLeishmania
dc.subjectCoinfecções
dc.subjectInfecções mistas
dc.subjectCocultura
dc.subjectHíbrido
dc.subjectComunicação intercelular
dc.subjectLeishmania
dc.subjectCoinfections
dc.subjectMixed infections
dc.subjectCoculture
dc.subjectHybrid
dc.subjectIntercellular communication
dc.titleInterspecies and Intrastrain Interplay among Leishmania spp. Parasites
dc.typeArticle


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