| dc.creator | Freitas, Luiz Antonio Rodrigues de | |
| dc.creator | Chevallier, Michele | |
| dc.creator | Louis, Dominique | |
| dc.creator | Grimaud, Jean-Alexis | |
| dc.date | 2016-07-08T19:01:58Z | |
| dc.date | 2016-07-22T13:13:54Z | |
| dc.date | 2016-07-08T19:01:58Z | |
| dc.date | 2016-07-22T13:13:54Z | |
| dc.date | 1986 | |
| dc.date.accessioned | 2023-09-26T20:26:46Z | |
| dc.date.available | 2023-09-26T20:26:46Z | |
| dc.identifier | FREITAS, L. A. R. et al. Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation. Liver, v. 6, p. 253-261, 1986. | |
| dc.identifier | 0106-9543 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/15072 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8857080 | |
| dc.description | Surgical bile flow restoration in extrahepatic biliary atresia (EHBA) does
not prevent the development of ongoing hepatic fibrosis and cirrhosis. Portal connective
matrix was studied on liver biopsies obtained from seven children submitted to
portoenterostomy. Electron microscopy and immunohistochemical techniques (using
specific antibodies directed against collagen isotypes and associated glycoproteins)
were performed. The study of extracellular and cellular components of connective
mat ix demonstrated the existence of two distinct areas according to their situation
with regard to ductular proliferation: loose connective matrix - mainly composed of
fi, iectin, type 111 collagen, type 1V collagen and laminin - associated with microvessels
and myofibroblasts proliferation characterized periportal zones adjacent to bile
ductules; in areas distant from ductular proliferation, connective matrix appeared
dense, composed of type I and type 111 collagen associated with fibroblasts. The
connective matrix pattern observed in periductular areas can be compared to that
described in cicatricial and hypertrophic processes where the myofibroblastic cell
population is known to play an important role in fibrosis development. Although the
connective matrix activation process remains unclear in EHBA, it may be suggested
that activation of a connective tissue cellular clone might be responsible for this portal
fibromatosis | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.rights | open access | |
| dc.subject | Collagen immunotyping | |
| dc.subject | Human extrahepatic | |
| dc.subject | Biliary atresia | |
| dc.subject | Portal connective tissue | |
| dc.subject | Ultrastructure | |
| dc.title | Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation | |
| dc.type | Article | |
