Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study

dc.creatorCavalcanti, A.
dc.creatorSantos, R.
dc.creatorMesquita, Z.
dc.creatorDuarte, A. L. B. P.
dc.creatorLucena-Silva, N.
dc.date2017-06-21T17:58:17Z
dc.date2017-06-21T17:58:17Z
dc.date2017
dc.date.accessioned2023-09-26T20:26:43Z
dc.date.available2023-09-26T20:26:43Z
dc.identifierCAVALCANTI, A. et al. Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study. Brazilian Journal of Medical and Biological Research, v. 50, n. 4, 2017.
dc.identifier1414-431X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19475
dc.identifier10.1590/1414-431X20175738
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857058
dc.descriptionChildhood-onset systemic lupus erythematosus (cSLE) exhibits an aggressive clinical phenotype and severe complications. This could be due to a pro-inflammatory cytokine milieu. Therefore, we determined plasma levels of Th1 (IL-2, IFN-γ, TNF), Th2 (IL-4), Th17 (IL-17A, IL-6), and Treg (IL-10) cytokines in a cohort of cSLE patients and healthy controls, and we evaluated the association between these cytokines and disease activity. We conducted a cross-sectional study with 51 cSLE patients from two pediatric rheumatology services. Ten cSLE patients participated in a longitudinal follow-up study. Blood samples were collected from the same patient during active and inactive disease. Disease activity was evaluated according to SLE Disease Activity Index 2000 (SLEDAI-2K). Cytokines levels were measured by cytometric bead array technique. cSLE patients had higher IL-6 (P<0.001) and IL-10 (P<0.001) levels than healthy controls. Patients with active disease had higher IL-6 and IL-10 levels than patients with inactive disease (P=0.001 and P=0.014, respectively) and the control group (both P<0.001). IL-6 (P=0.022), IL-10 (P=0.013), and IL-17A (P=0.041) levels were significantly higher during active than inactive disease. Linear regression analysis revealed IL-6 (P=0.002, 95%CI=0.006-0.025) and IL-10 (P=0.01 95%CI=0.021-0.150) as independent factors for increased SLEDAI-2K. IL-6, IL-10, and IL-17A are candidate biomarkers for disease activity in cSLE patients. This is the first longitudinal study to support their pivotal role in the pathogenesis of the disease.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCitocinas
dc.subjectLúpus eritematoso sistêmico de início na infância
dc.subjectAtividade de doença
dc.subjectSLEDAI-2K
dc.subjectInflamação
dc.subjectCytokines
dc.subjectChildhood-onset systemic lupus erythematosus
dc.subjectDisease activity
dc.subjectSLEDAI-2K
dc.subjectInflammation
dc.subjectLúpus Eritematoso Sistémico , Sistémico / sangue
dc.subjectCitocinas / sangue
dc.titleCytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study
dc.typeArticle


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