Importin-β and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits

dc.creatorNuovo, Gerard J.
dc.creatorAndrade, Cecilia Vianna de
dc.creatorThirukkumaran, Chandini
dc.creatorNicol, Alcina F.
dc.date2018-03-22T17:33:43Z
dc.date2018-03-22T17:33:43Z
dc.date2018
dc.date.accessioned2023-09-26T20:26:39Z
dc.date.available2023-09-26T20:26:39Z
dc.identifierNUOVO, Gerald J. et al. Importin-β and exportin-5 are indicators of acute viral infection: correlation of their detection with commercially available detection kits. Annals of Diagnostic Pathology, v. 34, p. 36-41, 2018.
dc.identifier1092-9134
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25469
dc.identifier10.1016/j.anndiagpath.2018.01.003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8857028
dc.descriptionThis work focused on immunohistochemistry markers of acute viral infections. Viral infected cells were detected by in situ based methods (reovirus, rabies virus) or cytologic changes (human papillomavirus, molloscum contagiosum virus, herpes simplex virus). Two proteins involved in nuclear trafficking, importin-β and exportin5, were detected in the infected cells for each virus and not in the control tissues. A wide variety of other proteins, including caspase-3, and bcl-2 family members (bcl2, bclX, MCL1, BAK, BAX, BIM, BAD) showed wide variations in expression among the different viral infections. Specificity of the importin-β and exportin-5 signals varied greatly with different commercially available peroxidase conjugates. It is concluded that immunohistochemistry detection of importin-β and exportin-5 may be useful markers of acute viral infection, which suggests that increased nuclear trafficking may be an important concomitant of viral proliferation.
dc.formatapplication/pdf
dc.languagepor
dc.publisherElsivier
dc.rightsrestricted access
dc.subjectVirus
dc.subjectImportin
dc.subjectExportin
dc.subjectBackground
dc.subjectHorseradish Peroxidase
dc.subjectVirus
dc.subjectHorseradish Peroxidase
dc.titleImportin-β and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits
dc.typeArticle


Este ítem pertenece a la siguiente institución