Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites

dc.creatorPeixoto, Juliana Figueiredo
dc.creatorOliveira, Adriane da Silva
dc.creatorOliveira, Luiz Filipe Gonçalves
dc.creatorSilva, Franklin Souza
dc.creatorAlves, Carlos Roberto
dc.date2023-06-01T18:16:26Z
dc.date2023-06-01T18:16:26Z
dc.date2023
dc.date.accessioned2023-09-26T20:26:33Z
dc.date.available2023-09-26T20:26:33Z
dc.identifierPEIXOTO, Juliana Figueiredo et al. Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites. The Brazilian Journal of Infection Diseases, v. 27, n. 2,: 102743, p. 1 - 9, Jan. 2023.
dc.identifier1413-8670
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/58871
dc.identifier10.1016/j.bjid.2023.102743
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856991
dc.descriptionNatural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological activities and represent a group of interesting molecules for new therapeutic propositions. Among these compounds, lapachol stands out as a molecule from the heartwood of Tabebuia sp. whose structural changes resulted in compounds considered promising, such as epoxy-a-lapachone (ELAP). The biological activity of ELAP has been demonstrated, so far, for parasitic protozoa such as Leishmania spp., Trypanosoma cruzi and Plasmodium spp., species causing diseases needing new drug development and adequate health policy. This work gathers in vitro and in vivo studies on these parasites, as well as the toxicity profile, and the probable mechanisms of action elucidated until then. The potential of ELAP-based technology alternatives for a further drug is discussed here.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier España, S.L.U.
dc.rightsopen access
dc.subjectNaftoquinona
dc.subjectTratamento
dc.subjectLeishimaniose
dc.subjectDoença de Chagas
dc.subjectMalária
dc.subjectEpóxi-a-lapachona
dc.subjectNaphthoquinone
dc.subjectEpoxy-a-lapachone
dc.subjectTreatment
dc.subjectLeishmaniasis
dc.subjectChagas disease
dc.subjectMalaria
dc.titleEpoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites
dc.typeArticle


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