Association of hepatosplenic schistosomiasis with HLA-DQB1*0201

dc.creatorSecor, William E
dc.creatorDel Corral, Helena
dc.creatorReis, Mitermayer Galvão dos
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorZimon, Alison E
dc.creatorMatos, E. Peixoto
dc.creatorReis, Eliana Almeida Gomes
dc.creatorCarmo, Theomira Mauadie de Azevedo
dc.creatorHirayama, Kenji
dc.creatorDavid, Roberta A
dc.creatorDavid, John R
dc.creatorHarn Junior, Donald A
dc.date2014-05-05T13:28:56Z
dc.date2014-05-05T13:28:56Z
dc.date1996
dc.date.accessioned2023-09-26T20:26:24Z
dc.date.available2023-09-26T20:26:24Z
dc.identifierSECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7576
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856937
dc.descriptionMajor histocompatibility class II alleles of 351 persons living in an area endemic for Schistosoma mansoni in northeastern Brazil were characterized at three loci (DRBl, DQAl, and DQBl). Contingency analyses were used to compare allele frequencies witfihigh egg excretion, proliferative response to schistosome soluble egg antigens (SEA), and occurrence of severe, biopsy-confirmed hepatosplenic disease. There were no associations of HLA-DR or DQ with egg excretion. Patients positive for DRBl*Ol, DQAl*0101, or DQBl*0501 were less likely to respond to SEA than was the overall study population. However, using stringent Bonferroni correction (multiplying P values by the number of alleles tested; P X 35), none of these associations with SEA responsiveness remained significant. Hepatosplenic disease was less likely in patients positive for DRBI*11 and was more likely in patients positive for DRBl*07 or DQBl*0201. However, only the DQBl*0201 association remained significant (odds ratio = 3.72; P < .005) following Bonferroni correction.
dc.formatapplication/pdf
dc.languageeng
dc.publisherThe University of Chicago Press
dc.rightsopen access
dc.subjectAntígenos HLA-DQ/genética
dc.subjectHepatopatias Parasitárias/imunologia
dc.subjectEsquistossomose mansoni/imunologia
dc.subjectEsplenopatias/imunologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectAlelos
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectCadeias beta de HLA-DQ
dc.subjectHumanos
dc.subjectLactente
dc.subjectAtivação Linfocitária
dc.titleAssociation of hepatosplenic schistosomiasis with HLA-DQB1*0201
dc.typeArticle


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