Cutaneous Manifestations of Human and Murine Leishmaniasis

dc.creatorScorza, Breanna M
dc.creatorCarvalho Filho, Edgar Marcelino
dc.creatorWilson, Mary E
dc.date2017-07-11T13:42:16Z
dc.date2017-07-11T13:42:16Z
dc.date2017
dc.date.accessioned2023-09-26T20:25:54Z
dc.date.available2023-09-26T20:25:54Z
dc.identifierSCORZA, B. M.; CARVALHO FILHO, E. M.; WILSON, M. E. Cutaneous Manifestations of Human and Murine Leishmaniasis. International Journal of Molecular Sciences, v. 18, p. 1296, 2017.
dc.identifier1661-6596
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20038
dc.identifier10.3390/ijms18061296
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856748
dc.descriptionNational Institutes of Health (NIH) grant AI076233, and by Merit Review grants 5I01BX001983-02 and 2I01BX000536 from the Department of Veterans’ Affairs (MEW). Studies were performed in part while B.M.S. was supported with funds from NIH T32 AI07511
dc.descriptionThe leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectLeishmania
dc.subjectLeishmaniose cutânea
dc.subjectLeishmaniose mucosa
dc.subjectLeishmaniose difusa
dc.subjectLeishmaniose disseminada
dc.subjectPele
dc.subjectKala-azar
dc.subjectImunologia
dc.subjectLeishmania
dc.subjectCutaneous leishmaniasis
dc.subjectMucosal leishmaniasis
dc.subjectDiffuse leishmaniasis
dc.subjectDisseminated leishmaniasis
dc.subjectDTH-delayed type hypersensitivity skin test
dc.subjectLST-Leishmania skin test
dc.subjectPost-kala-azar dermal leishmaniasis
dc.subjectKala-azar
dc.subjectSkin immunology
dc.titleCutaneous Manifestations of Human and Murine Leishmaniasis
dc.typeArticle


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