Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age

dc.creatorMartins, Adenilda Lima Lopes
dc.creatorGrassi, Maria Fernanda Rios
dc.creatorFirmino, Alisson de Aquino
dc.creatorAraujo, Jean Paulo Lacerda
dc.creatorPaixao, Taiane Silva
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorBoa-Sorte, Ney
dc.date2018-10-11T13:43:00Z
dc.date2018-10-11T13:43:00Z
dc.date2018
dc.date.accessioned2023-09-26T20:25:19Z
dc.date.available2023-09-26T20:25:19Z
dc.identifierMARTINS, A. L. L. et al. Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age. Sexual Medicine, e1-18, 2018.
dc.identifier2050-1161
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29514
dc.identifier10.1016/j.esxm.2018.07.002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856532
dc.descriptionHuman T-lymphotropic virus (HTLV)-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder that mostly affects women. This disease is characterized by a progressive loss of motor function and disruptions in sensory function in the lower limbs. HTLV-1 is also associated with isolated neurologic dysfunctions, overactive bladder, and erectile dysfunction. The occurrence of sexual dysfunction in HTLV-1-infected women remain unclear. Aim: To investigate associations between HTLV-1 infection and sexual dysfunction in both asymptomatic infected women and those diagnosed with HAM/TSP compared with uninfected women. Methods: HTLV-1einfected and uninfected women were assessed for sexual dysfunction using the Female Sexual Function Index instrument. Sexual dysfunction was considered if global Female Sexual Function Index scores were <26.5. Crude and adjusted prevalence ratios (PR) with 95% CI were calculated to identify associations between sexual dysfunction (outcome) and HTLV infection statuseasymptomatic or HAM/TSP (main exposure), compared with uninfected women, and adjusted by sociodemographic and/or clinical characteristics (covariables). Results: HTLV-1einfected women (n ¼ 72; 57 asymptomatic; 15 HAM/TSP) and HTLV-1 uninfected women (n ¼ 49) were evaluated. The overall sexual dysfunction prevalence was 53.7% (65/121), which was higher in the HAM/TSP group (80.0%; adjusted PR 1.89; 95% CI 1.23e2.90) when compared with non-infected individuals (44.9%). Sexual dysfunction was found in 54.4% of the HTLV-1einfected asymptomatic women (PR 1.21; 95% CI 0.82e1.79). Sexual dysfunction was associated with income lower than 1 minimal wage (wUS $300, October 2017) and number of previous birthday. Conclusion: The obtained results indicate that sexual dysfunction is associated with HAM/TSP in women infected with HTLV-1 of reproductive age.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectDisfunção Sexual
dc.subjectVírus Linfotrópico T Humano-1e Mielopatia Associada / Paraparesia Espástica Tropical;
dc.subjectÍndice de Função Sexual Feminina
dc.subjectVírus Linfotrópico T Humano-1
dc.subjectPrevalência
dc.subjectSexual Dysfunction
dc.subjectHuman T-Lymphotropic Virus-1eAssociated Myelopathy/Tropical Spastic Paraparesis
dc.subjectFemale Sexual Function Index
dc.subjectHuman T-Lymphotropic Virus-1
dc.subjectPrevalence
dc.titleHuman T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age
dc.typeArticle


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