Regulatory T cells: Friends or foe in human Mycobacterium leprae infection?

dc.creatorChaves, Ana Tereza
dc.creatorRibeiro Junior, Atvaldo Fernandes
dc.creatorLyon, Sandra
dc.creatorMedeiros, Nayara Ingrid de
dc.creatorCosta, Fábio Cassirer
dc.creatorPaula, Karina S.
dc.creatorAlecrim, Edilamar Silva de
dc.creatorMenezes, Cristiane Alves Silva
dc.creatorOliveira, Rodrigo Correa de
dc.creatorRocha, Manoel Otávio da Costa
dc.creatorEstanislau, Juliana de Assis Silva Gomes
dc.date2018-03-09T19:27:09Z
dc.date2018-03-09T19:27:09Z
dc.date2018
dc.date.accessioned2023-09-26T20:25:06Z
dc.date.available2023-09-26T20:25:06Z
dc.identifierCHAVES, Ana Tereza et al. Regulatory T cells: Friends or foe in human Mycobacterium leprae infection? Immunobiology, v. 223, n. 4-5, p. 397-404, 2018
dc.identifier0171-2985
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25214
dc.identifier10.1016/j.imbio.2017.11.002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856448
dc.descriptionRegulatory T cells (Tregs) are known to control immune responses by suppressing the antigen-presenting and effector T cells. Some mechanisms adopted by Tregs in combating Mycobacterium infections have been proposed. Nevertheless, in M. leprae infection, also known as leprosy or Hansen’s disease, the role of Tregs has not been completely elucidated. Using multicolor flow cytometry, we evaluated the expression of different cell surface and intracellular molecules present in Tregs from peripheral blood samples of leprosy patients. Before initiating treatment, thirteen new cases of leprosy were grouped according to the Ridley–Jopling classification in to the paucibacilary (PB) or multibacilary (MB) group. Fifteen non-infected individuals (NI) were included as control subjects. Tregs were higher in the MB group than in the NI group. Tregs also co-expressed high amounts of PD1 and PDL-1, indicating that these cells could induce apoptosis of effector cells and simultaneously prevent their own apoptosis. Our data showed that compared to the NI group, Tregs from the PB group expressed higher levels of CD95L, which may be associated with other apoptotic pathways that may decrease Tregs in these patients. Correlation analysis reinforced that PD1 and CD95L are efficient apoptosis' pathway that decreased levels of Tregs in the NI and PB groups. We also observed significant differences in cytokine expression of Tregs from the PB and MB groups. Compared to the NI group, Tregs from the MB group showed higher IL-17 expression; however, compared to the PB group, the expression of IL-10 in Tregs from the MB group was lower, suggesting inefficient control of inflammation. Therefore, we concluded that different pathways were involved in Treg-induced suppression of leprosy. Moreover, Treg-mediated regulation of inflammation via IL-10 and IL-17 expression in leprosy patients was inefficient. Thus, we propose that during M. leprae infection, Tregs may impair the immune responses elicited against this bacillus, favor bacterial replication, and aid in persistence of a disseminated multibacillary disease.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectHansen
dc.subjectRegulatory T lymphocytes
dc.subjectApoptotic pathways
dc.subjectLeprosy
dc.subjectImmune regulation
dc.subjectCytokines
dc.subjectTregs
dc.titleRegulatory T cells: Friends or foe in human Mycobacterium leprae infection?
dc.typeArticle


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