Interaction between areas of the central nervous system in the control of water intake and arterial pressure in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCamargo, L. A A
dc.creatorMenani, José Vanderlei
dc.creatorSaad, W. A.
dc.date2014-05-26T22:03:36Z
dc.date2016-10-25T18:11:48Z
dc.date2014-05-26T22:03:36Z
dc.date2016-10-25T18:11:48Z
dc.date1984-01-01
dc.date.accessioned2017-04-06T00:40:01Z
dc.date.available2017-04-06T00:40:01Z
dc.identifierJournal of Physiology, v. VOL. 350, p. 1-8.
dc.identifier0022-3751
dc.identifierhttp://hdl.handle.net/11449/63651
dc.identifierhttp://acervodigital.unesp.br/handle/11449/63651
dc.identifier2-s2.0-0021287234
dc.identifierhttp://jp.physoc.org/content/350/1/1.long
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/885636
dc.description1. Water intake induced by injection of 0.2 M-NaCl into the lateral preoptic area was increased by the injection of angiotensin II into the subfornical organ of rats. The injection of hypertonic saline solution into the subfornical organ increased water intake. However, the increase was lower than when the solution was injected into the lateral preoptic area. The injection of 4 μg angiotensin II into the lateral preoptic area further augmented this effect. 2. Injection of angiotensin II into the subfornical organ caused a rise in blood pressure which preceded the thirst-inducing effect. The injection of 0.2 M NaCl into the subfornical organ caused no changes in blood pressure, whereas the injection of angiotensin II into the lateral preoptic area caused some increase. 3. Dehydration of the lateral preoptic area by means of 0.2 M NaCl in combination with intravenous infusion of angiotensin II caused a summation of effects in terms of the water intake, without changing cardiovascular alterations induced by the infusion of angiotensin II. A summation of effects in the water intake, but not in blood pressure, was also observed when 0.5 M NaCl was infused intravenously in combination with the injection of angiotensin II into the subfornical organ and into the lateral preoptic area. 4. The results indicate that there are interactions between the subfornical organ and lateral preoptic area in the regulation of cardiovascular and thirst mechanisms.
dc.languageeng
dc.relationJournal of Physiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectangiotensin
dc.subjectangiotensin ii [5 isoleucine]
dc.subjectsodium chloride
dc.subjectanimal experiment
dc.subjectblood pressure
dc.subjectcardiovascular system
dc.subjectcentral nervous system
dc.subjectdose response
dc.subjectdrug administration
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectdrug potentiation
dc.subjectdrug response
dc.subjectfluid intake
dc.subjectintracerebral drug administration
dc.subjectintravenous drug administration
dc.subjectnervous system
dc.subjectnonhuman
dc.subjectpreoptic area
dc.subjectrat
dc.subjectsubfornical organ
dc.titleInteraction between areas of the central nervous system in the control of water intake and arterial pressure in rats
dc.typeOtro


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