Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.

dc.creatorSoares, Milena Botelho Pereira
dc.creatorMota, Kátia N. Silva
dc.creatorLima, Ricardo Santana de
dc.creatorBellintani, Moema Cortizo
dc.creatorPontes-de-Carvalho, Lain Carlos
dc.creatorSantos, Ricardo Ribeiro dos
dc.date2012-09-19T19:16:06Z
dc.date2012-09-19T19:16:06Z
dc.date2001
dc.date.accessioned2023-09-26T20:24:48Z
dc.date.available2023-09-26T20:24:48Z
dc.identifierSOARES, M.B. et al. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. American Journal of Pathology, v. 159, n. 2, p. 703-709, Aug. 2001.
dc.identifier0002-9440
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5531
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856339
dc.descriptionChronic chagasic cardiomyopathy (CChC) is characterized by an inflammatory reaction which may eventually lead to heart enlargement, arrythmia, and death. As described herein, interleukin-4-deficient mice mount increased specific T helper (Th) 1 immune responses when infected with Trypanosoma cruzi, as compared to wild-type mice. Interestingly, these mice had reduced parasitism and mortality and exacerbated inflammation in their hearts, demonstrating a clear dissociation between inflammation and parasite load. The modulation of these phenomena so as to maximize host and parasite survivals may depend on a fine balance between Th responses, in which a Th1 response will, on one hand, control parasitism and, on the other hand, enhance heart inflammation throughout the course of the infection
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCardiomiopatia Chagásica/imunologia
dc.subjectInflamação/imunologia
dc.subjectInterleucina-4/fisiologia
dc.subjectParasitemia/imunologia
dc.subjectLinfócitos T Auxiliares-Indutores/imunologia
dc.subjectAnimais
dc.subjectCardiomiopatia Chagásica/genética
dc.subjectCardiomiopatia Chagásica/patologia
dc.subjectImunidade Inata/genética
dc.subjectImunidade Inata/imunologia
dc.subjectInflamação/patologia
dc.subjectInterleucina-4/deficiência
dc.subjectInterleucina-4/genética
dc.subjectAtivação Linfocitária
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectCamundongos Knockout
dc.subjectCamundongos Nus
dc.subjectMiocardite/genética
dc.subjectMiocardite/imunologia
dc.subjectMiocardite/patologia
dc.subjectParasitemia/patologia
dc.subjectFatores de Tempo
dc.subjectTrypanosoma cruzi
dc.titleModulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
dc.typeArticle


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