Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients

dc.creatorGuedes, Paulo Marcos Matta
dc.creatorAndrade, Cléber Mesquita de
dc.creatorNunes, Daniela Ferreira
dc.creatorPereira, Nathalie de Sena
dc.creatorQueiroga, Tamyres Bernadete Dantas
dc.creatorCoelho, George Luiz Lins Machado
dc.creatorNascimento, Manuela Sales Lima
dc.creatorMatta, Maria Adelaide Do Valle
dc.creatorCâmara, Antônia Cláudia Jácome da
dc.creatorChiari, Egler
dc.creatorGalvão, Lúcia Maria da Cunha
dc.date2016-06-19T19:21:52Z
dc.date2016-07-08T12:21:49Z
dc.date2016-06-19T19:21:52Z
dc.date2016-07-08T12:21:49Z
dc.date2016
dc.date.accessioned2023-09-26T20:24:35Z
dc.date.available2023-09-26T20:24:35Z
dc.identifierGUEDES, Paulo Marcos Matta; et al. Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients. PLoS Negl Trop Dis., v.10, n.4, 18p, e0004669. Apr. 2016.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/14513
dc.identifier10.1371/journal.pntd.0004669
dc.identifier1935-2735
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856264
dc.descriptionIschemic strokes have been implicated as a cause of death in Chagas disease patients. Inflammation has been recognized as a key component in all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. In this study, we evaluated the association between inflammatory markers and the death risk (DR) and stroke risk (SR) of patients with different clinical forms of chronic Chagas disease. The mRNA expression levels of cytokines, transcription factors expressed in the adaptive immune response (Th1, Th2, Th9, Th17, Th22 and regulatory T cell), and iNOS were analyzed by realtime PCR in peripheral blood mononuclear cells of chagasic patients who exhibited the indeterminate, cardiac, digestive and cardiodigestive clinical forms of the disease, and the levels of these transcripts were correlated with the DR and SR. Cardiac patients exhibited lowermRNA expression levels of GATA-3, FoxP3, AHR, IL-4, IL-9, IL-10 and IL-22 but exhibited higher expression of IFN-γ and TNF-α compared with indeterminate patients. Digestive patients showed similar levels of GATA-3, IL-4 and IL-10 than indeterminate patients. Cardiodigestive patients exhibited higher levels of TNF-α compared with indeterminate and digestive patients. Furthermore, we demonstrated that patients with high DR and SR exhibited lower GATA-3, FoxP3, and IL-10 expression and higher IFN-γ, TNF-α and iNOS mRNA expression than patients with low DR and SR. A negative correlation was observed between Foxp3 and IL-10 mRNA expression and the DR and SR. Moreover, TNF-α and iNOS expression was positively correlated with DR and SR. Our data suggest that an inflammatory imbalance in chronic Chagas disease patients is associated with a high DR and SR. This study provides a better understanding of the stroke pathobiology in the general population and might aid the development of therapeutic strategies for controlling the morbidity and mortality of Chagas disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectRiscos de morte
dc.subjectRiscos de acidente vascular encefálico
dc.subjectChronic Chagas Disease
dc.subjectInflammation
dc.subjectTrypanosoma cruzi
dc.subjectRisks of Stroke
dc.subjectRisks of Death
dc.subjectTrypanosoma cruzi
dc.subjectChagas Disease
dc.subjectInflamação
dc.titleInflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients
dc.typeArticle


Este ítem pertenece a la siguiente institución