Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected

dc.creatorPompeu, Margarida Maria de Lima
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorSantos, M. L. V
dc.creatorBarral, Aldina Maria Prado
dc.creatorBarral Netto, Manoel
dc.date2014-07-10T16:43:11Z
dc.date2014-07-10T16:43:11Z
dc.date1992
dc.date.accessioned2023-09-26T20:24:30Z
dc.date.available2023-09-26T20:24:30Z
dc.identifierPOMPEU, M. L. et al. Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected. Experimental Parasitology, v. 74, n. 2, p. 169-176, 1992.
dc.identifier0014-4894
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7908
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856221
dc.descriptionIn vitro studies have shown that both macrophage activation and destruction of parasitized macrophages lead to leishmania destruction. The relative role played by such mechanisms in vivo have not been properly evaluated. We took advantage of the model of intravenous immunization with solubilized leishmanial antigen which renders partially resistant the otherwise highly susceptible BALB/c mice to address this issue avoiding the interference of different genetic backgrounds. Leishmania destruction occurred in three situations: destruction of the parasitized macrophage, which were in close contact with lymphocytes or eosinophils; extracellular damage, always surrounded by small foci of granulocytes; and parasite damage inside activated macrophages. Destruction of the parasitized macrophages was frequently seen in immunized and protected animals. Our observations suggest that destruction of parasite-loaded macrophages is an important mechanism of host protection in experimental cutaneous leishmaniasis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademic Press Inc.
dc.rightsopen access
dc.subjectLeishmania amazonensis;
dc.subjectLeishmaniasis
dc.subjectImmunization
dc.subjectLeishmania
dc.subjectTegumentary leishmaniasis
dc.subjectExperimental leishmaniasis
dc.subjectImunização
dc.subjectLeishmania mexicana/imunologia
dc.subjectLeishmaniose Cutânea/imunologia
dc.subjectAtivação de Macrófagos
dc.subjectMacrófagos/imunologia
dc.subjectAnimais
dc.subjectEosinófilos/imunologia
dc.subjectGranulócitos/imunologia
dc.subjectLeishmania mexicana/ultraestrutura
dc.subjectMacrófagos/parasitologia
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectMicroscopia Eletrônica
dc.titleLeishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
dc.typeArticle


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