CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors.

dc.creatorMello, Leonardo Araújo
dc.creatorFigueiredo, Andreia Leal
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorGurgel, Clarissa Araújo Silva
dc.creatorMartins, Manoela Domingues
dc.creatorFigueiredo, Claudia Roberta Leite Vieira de
dc.creatorCury, Patrícia Ramos
dc.creatorAlbuquerque Junior, Ricardo Luiz Cavalcanti de
dc.creatorRamalho, Luciana Maria Pedreira
dc.creatorSantos, Jean Nunes dos
dc.date2014-11-19T16:39:30Z
dc.date2014-11-19T16:39:30Z
dc.date2013
dc.date.accessioned2023-09-26T20:24:08Z
dc.date.available2023-09-26T20:24:08Z
dc.identifierMELO, L. A. et al. CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 42, n. 6, p. 454-461, 2013.
dc.identifier1600-0714
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8916
dc.identifier10.1111/jop.12033
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856108
dc.descriptionBACKGROUND: Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. OBJECTIVE AND METHODS: The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT). RESULTS: The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann-Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann-Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test). CONCLUSION: A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors.
dc.formatapplication/pdf
dc.languageeng
dc.publisherJohn Wiley & Sons Ltd
dc.rightsopen access
dc.subjectDendritic cell
dc.subjectE-cadherin
dc.subjectLangerhans cell
dc.subjectOdontogenic tumors
dc.subjectAmeloblastoma/patologia
dc.subjectAntígenos CD1/análise
dc.subjectCaderinas/análise
dc.subjectCélulas de Langerhans/patologia
dc.subjectTumores Odontogênicos/patologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso de 80 Anos ou mais
dc.subjectIdoso
dc.subjectAdesão Celular/fisiologia
dc.subjectContagem de Células
dc.subjectForma Celular
dc.subjectCriança
dc.subjectCélulas Dendríticas/patologia
dc.subjectCélulas Epiteliais/patologia
dc.subjectFeminino
dc.subjectHumanos
dc.subjectImuno-Histoquímica
dc.subjectQueratinócitos/patologia
dc.subjectMasculino
dc.subjectNeoplasias Mandibulares/patologia
dc.subjectCisto Odontogênico Calcificante/patologia
dc.titleCD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors.
dc.typeArticle


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