The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle

dc.creatorAbrantes, Juliana L.
dc.creatorBarbosa, Jussara
dc.creatorCavalcanti, Diana
dc.creatorPereira, Renato C.
dc.creatorFontes, Carlos L. Frederico
dc.creatorTeixeira, Valeria L.
dc.creatorSouza, Thiago Moreno L.
dc.creatorPaixão, Izabel C. P.
dc.date2018-03-13T17:49:15Z
dc.date2018-03-13T17:49:15Z
dc.date2010
dc.date.accessioned2023-09-26T20:23:54Z
dc.date.available2023-09-26T20:23:54Z
dc.identifierABRANTES, Juliana L. et al. The Effects of the Diterpenes Isolated from the Brazilian Brown Algae Dictyota pfaffii and Dictyota menstrualis against the Herpes Simplex Type-1 Replicative Cycle. Planta Med., v.76, p.339–344, 2010.
dc.identifier0032-0943
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25294
dc.identifier10.1055/s-0029-1186144
dc.identifier1439-0221
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856013
dc.descriptionWe describe in this paper that the diterpenes 8,10,18-trihydroxy-2,6-dolabelladiene ( 1) and (6 R)-6-hydroxydichotoma-4,14-diene-1,17-dial ( 2), isolated from the marine algae DICTYOTA PFAFFII and D. MENSTRUALIS, respectively, inhibited HSV-1 infection in Vero cells. We initially observed that compounds 1 and 2 inhibited HSV-1 replication in a dose-dependent manner, resulting in EC (50) values of 5.10 and 5.90 microM, respectively, for a multiplicity of infection (MOI) of 5. Moreover, the concentration required to inhibit HSV-1 replication was not cytotoxic, resulting in good selective index (SI) values. Next, we found that compound 1 sustained its anti-herpetic activity even when added to HSV-1-infected cells at 6 h after infection, while compound 2 sustained its activity for up to 3 h after infection, suggesting that these compounds inhibit initial events during HSV-1 replication. We also observed that both compounds were incapable of impairing HSV-1 adsorption and penetration. In addition, the tested molecules could decrease the contents of some HSV-1 early proteins, such as UL-8, RL-1, UL-12, UL-30 and UL-9. Our results suggest that the structures of compounds 1 and 2, Brazilian brown algae diterpenes, might be promising for future antiviral design.
dc.formatapplication/pdf
dc.languageeng
dc.publisherGeorg Thieme Verlag
dc.rightsopen access
dc.subjectDiterpenos
dc.subjectHerpes Simples
dc.subjectFeófitas
dc.subjectBrasil
dc.subjectAntivirais
dc.subjectHerpes simplex
dc.subjectDiterpenes
dc.subjectBrown algae
dc.subjectBrazil
dc.subjectantiviral
dc.titleThe effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle
dc.typeArticle


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