Overt and occult hepatitis B virus infection among treatment-naïve HIV-infected patients in Brazil

dc.creatorOliveira, Marina Pedroso
dc.creatorLemes, Pollyanne Sousa
dc.creatorMatos, Márcia Alves Dias
dc.creatorDel-Rios, Nativa Helena Alves
dc.creatorCarneiro, Megmar Aparecida Santos
dc.creatorSilva, Ágabo Macedo Costa
dc.creatorLopes, Carmen Luci Rodrigues
dc.creatorTeles, Sheila Araújo
dc.creatorAires, Rodrigo Sebba
dc.creatorLago, Bárbara Vieira
dc.creatorAraujo, Natalia Motta
dc.creatorMartins, Regina Maria Bringel
dc.date2016-12-27T10:28:01Z
dc.date2016-12-27T10:28:01Z
dc.date2016
dc.date.accessioned2023-09-26T20:23:04Z
dc.date.available2023-09-26T20:23:04Z
dc.identifierOLIVEIRA, Marina Pedroso; et al. Overt and Occult Hepatitis B Virus Infection Among Treatment-Naıve HIV-Infected Patients in Brazil. Journal of Medical Virology, v.88, p.1222-1229, 2016.
dc.identifier0146-6615
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16567
dc.identifier10.1002/jmv.24462
dc.identifier1096-9071
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855690
dc.descriptionAlthough hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infection is common, only few data are available on HBV among HIV patients including occult hepatitis B infection (OBI), regardless of serological markers. This study aims to determine the prevalence of OBI and overall HBV infection, associated factors, HBV genotypes, and surface (S) gene mutations in a population of treatment-naïve HIV-infected patients in Brazil. A cross-sectional study was conducted in treatment-naïve HIV-infected patients in Central Brazil. All samples were tested for HBV serological markers and HBV DNA. Sequence analysis of the S gene and overlapping polymerase gene was preformed. Overall, 25.1% (127/505) of the patients had markers of current or previous HBV infection, which was associated with age over 40 years, history of injection drug use, and homosexual sex. The hepatitis B surface antigen (HBsAg) seroprevalence was 4.9% (25/505). HBV DNA was detected in 39 out of 505 patients: 20 of them were HBsAg-positive and 19 were HBsAg-negative, resulting in an OBI prevalence of 3.8%. Patients with OBI had significantly higher HCV seropositivity rate compared to HBsAg-positive patients. Sequencing of the S gene revealed Y100C, T131N, and D144A mutations. One patient had the M204I and L180M drug-resistance mutations (polymerase). HBV genotypes A (A1, A2), D (D2, D3), and F (F2) were identified. In conclusion, OBI represented almost half of all HBV infections with detectable HBV DNA, suggesting that hepatitis B diagnosis in HIV patients should include in addition to serological markers the detection of HBV DNA.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectHIV
dc.subjectHepatite B
dc.subjectInfecção oculta
dc.subjectHIV
dc.subjecthepatitis B
dc.subjectoccult infection
dc.subjectHBV DNA
dc.titleOvert and occult hepatitis B virus infection among treatment-naïve HIV-infected patients in Brazil
dc.typeArticle


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