| dc.creator | Junqueira, Caroline Furtado | |
| dc.creator | Barbosa, Rafael Polidoro Alves | |
| dc.creator | Maia, Guilherme de Castro | |
| dc.creator | Absalon, Sabrina | |
| dc.creator | Liang, Zhitao | |
| dc.creator | Santara, Sumit Sen | |
| dc.creator | Crespo, Ângela | |
| dc.creator | Pereira, Dhelio Batista | |
| dc.creator | Gazzinelli, Ricardo Tostes | |
| dc.creator | Dvorin, Jeffrey D | |
| dc.creator | Lieberman, Judy | |
| dc.date | 2022-02-15T14:58:29Z | |
| dc.date | 2022-02-15T14:58:29Z | |
| dc.date | 2021 | |
| dc.date.accessioned | 2023-09-26T20:22:30Z | |
| dc.date.available | 2023-09-26T20:22:30Z | |
| dc.identifier | JUNQUEIRA, Caroline Furtado et al. γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nature Immunology, v. 22, n. 3, p. 347-357, 2021. doi: 10.1038/s41590-020-00847-4. | |
| dc.identifier | 1529-2908 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/51211 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8855464 | |
| dc.description | Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum-infected patients. Although previous studies suggested that γδ2 T cells help control erythrocytic malaria, whether γδ2 T cells recognize infected red blood cells (iRBCs) was uncertain. Here we show that iRBCs stained for the phosphoantigen sensor butyrophilin 3A1 (BTN3A1). γδ2 T cells formed immune synapses and lysed iRBCs in a contact, phosphoantigen, BTN3A1 and degranulation-dependent manner, killing intracellular parasites. Granulysin released into the synapse lysed iRBCs and delivered death-inducing granzymes to the parasite. All intra-erythrocytic parasites were susceptible, but schizonts were most sensitive. A second protective γδ2 T cell mechanism was identified. In the presence of patient serum, γδ2 T cells phagocytosed and degraded opsonized iRBCs in a CD16-dependent manner, decreasing parasite multiplication. Thus, γδ2 T cells have two ways to control blood-stage malaria-γδ T cell antigen receptor (TCR)-mediated degranulation and phagocytosis of antibody-coated iRBCs. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Nature America Inc | |
| dc.rights | restricted access | |
| dc.title | γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis | |
| dc.type | Article | |
