Zika virus replication in the mosquito Culex quinquefasciatus in Brazil

dc.creatorGuedes, Duschinka R. D.
dc.creatorPaiva, Marcelo H S.
dc.creatorDonato, Mariana Ma
dc.creatorBarbosa, Priscilla P.
dc.creatorKrokovsky, Larissa
dc.creatorRocha, Sura W. Dos S.
dc.creatorSaraiva, Karina L. A.
dc.creatorCrespo, Mônica M.
dc.creatorRezende, Tatiana M. T.
dc.creatorWallau, Gabriel da Luz
dc.creatorBarbosa, Rosângela M. R.
dc.creatorOliveira, Cláudia M. F.
dc.creatorMelo-Santos, Maria A. V.
dc.creatorPena, Lindomar José
dc.creatorCordeiro, Marli T.
dc.creatorFranca, Rafael F. de O.
dc.creatorOliveira, André L. S. de
dc.creatorPeixoto, Christina A.
dc.creatorLeal, Walter S.
dc.creatorAyres, Constância F. J.
dc.date2018-03-19T13:44:01Z
dc.date2018-03-19T13:44:01Z
dc.date2017
dc.date.accessioned2023-09-26T20:22:26Z
dc.date.available2023-09-26T20:22:26Z
dc.identifierGUEDES, D. R. et al. Zika virus replication in the mosquito Culex quinquefasciatus in Brazil. Emerging Microbes & Infections, v. 6, n. 8, p. e69, 9 Aug. 2017.
dc.identifier2222-1751
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25371
dc.identifier10.1038/emi.2017.59
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855432
dc.descriptionEste trabalho foi parcialmente apoiado pela Fundação de Amparo à Pesquisa do Estado de Pernambuco (FACEPE, APQ-1608-2.13 / 15 e APQ-0085-2.13 / 16 à CFJA, APQ-345-2.13 / 13 a MAVMS e APQ-0078 -2.02 / 16 a GLW), o Conselho Nacional de Pesquisa e Desenvolvimento do Brasil (CNPq; concessão 441100 / 2016-3) eo Instituto Nacional de Alergia e Doenças Infecciosas dos Institutos Nacionais de Saúde (R01AI095514 e 1R21AI128931-01 a WSL) . A CFJA ea PAC foram apoiadas por bolsas de produtividade do CNPq.
dc.descriptionZika virus (ZIKV) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mosquito is considered to be the main vector to humans worldwide; however, there is evidence that other mosquito species, including Culex quinquefasciatus, transmit the virus. To test the potential of Cx. quinquefasciatus to transmit ZIKV, we experimentally compared the vector competence of laboratory-reared Ae. aegypti and Cx. quinquefasciatus. Interestingly, we were able to detect the presence of ZIKV in the midgut, salivary glands and saliva of artificially fed Cx. quinquefasciatus. In addition, we collected ZIKV-infected Cx. quinquefasciatus from urban areas with high microcephaly incidence in Recife, Brazil. Corroborating our experimental data from artificially fed mosquitoes, ZIKV was isolated from field-caught Cx. quinquefasciatus, and its genome was partially sequenced. Collectively, these findings indicate that there may be a wider range of ZIKV vectors than anticipated.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAedes
dc.subjectCulex
dc.subjectmicrocefalia
dc.subjectcompetência vetorial
dc.subjectZika
dc.subjectAedes
dc.subjectCulex
dc.subjectmicrocephaly
dc.subjectvector competence
dc.subjectZika
dc.subjectAedes/virologia
dc.subjectAnimais
dc.subjectBrasil / epidemiologia
dc.subjectCulex / virologia
dc.subjectGenoma, viral
dc.subjectHumanos
dc.subjectMicrocefalia / epidemiologia
dc.subjectVetores de mosquito / fisiologia
dc.subjectVetores de mosquito / virologia
dc.subjectSaliva / virologia
dc.subjectGlândulas salivares / virologia
dc.subjectAnálise de Sequência, DNA
dc.subjectReplicação de vírus
dc.subjectVírus Zika / genética
dc.subjectVírus Zika / isolamento e purificação
dc.subjectVírus Zika / fisiologia
dc.subjectInfecção por vírus Zika / epidemiologia
dc.subjectInfecção por vírus Zika / transmissão
dc.subjectInfecção por vírus Zika / virologia
dc.titleZika virus replication in the mosquito Culex quinquefasciatus in Brazil
dc.typeArticle


Este ítem pertenece a la siguiente institución