Role of NO Synthase in the Development of Trypanosoma cruzi– Induced Cardiomyopathy in Mice

dc.creatorDurand, Jorge L.
dc.creatorMukherjee, Shankar
dc.creatorCommodari, Fernando
dc.creatorSouza, Andrea P. de
dc.creatorZhao, Dazhi
dc.creatorMachado, Fabiana S.
dc.creatorTanowitz, Herbert B.
dc.creatorJelicks, Linda A.
dc.date2018-09-21T23:43:39Z
dc.date2018-09-21T23:43:39Z
dc.date2009
dc.date.accessioned2023-09-26T20:22:23Z
dc.date.available2023-09-26T20:22:23Z
dc.identifierDURAND, Jorge L. et al. Role of NO Synthase in the Development of Trypanosoma cruzi– Induced Cardiomyopathy in Mice. Am J Trop Med Hyg., v.80, n.5, p,782-787, May 2009.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28981
dc.identifier1476-1645
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855409
dc.descriptionTrypanosoma cruzi infection results in an increase in myocardial NO and intense inflammation. NO modulates the T. cruzi–induced myocardial inflammatory reaction. NO synthase (NOS)1-, NOS2-, and NOS3-null mice were infected with T. cruzi (Brazil strain). Infected NOS1-null mice had increased parasitemia, mortality, and left ventricular inner diameter (LVID). Chronically infected NOS1- and NOS2-null and wild-type mice (WT) exhibited increased right ventricular internal diameter (RVID), although the fold increase in the NOS2-null mice was smaller. Infected NOS3null mice exhibited a significant reduction both in LVID and RVID. Reverse transcriptasepolymerase chain reaction showed expression of NOS2 and NOS3 in hearts of infected NOS1-null and WT mice, whereas infected NOS2-null hearts showed little change in expression of other NOS isoforms. Infected NOS3-null hearts showed an increase only in NOS1 expression. These results may indicate different roles for NOS isoforms in T. cruzi–induced cardiomyopathy.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherThe American Society of Tropical Medicine and Hygiene
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectCardiomiopatia
dc.subjectInflamação
dc.subjectCamundongos
dc.subjectÓxido Nítrico Sintase
dc.subjectTrypanosoma cruzi
dc.subjectCardiomyopathy
dc.subjectinflammation
dc.subjectMice
dc.subjectNO synthase
dc.titleRole of NO Synthase in the Development of Trypanosoma cruzi– Induced Cardiomyopathy in Mice
dc.typeArticle


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