Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis

dc.creatorSilva, Icaro Bonyek
dc.creatorNunes, Sara
dc.creatorSantos, Reinan L
dc.creatorLima, Filipe R
dc.creatorLago, Alexsandro
dc.creatorSilva, Juliana
dc.creatorCarvalho, Lucas P
dc.creatorArruda, Sergio Marcos
dc.creatorSerezani, Henrique C
dc.creatorCarvalho, Edgar Marcelino de
dc.creatorBrodskyn, Claudia Ida
dc.creatorTavares, Natalia M
dc.date2020-07-16T13:04:37Z
dc.date2020-07-16T13:04:37Z
dc.date2020
dc.date.accessioned2023-09-26T20:22:22Z
dc.date.available2023-09-26T20:22:22Z
dc.identifierSILVA, Icaro Bonyek et al. production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis. Emerging Microbes & Infections, v. 9, 2020.
dc.identifier: 2222-1751
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42274
dc.identifier10.1080/22221751.2020.1773744
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855405
dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) #1] under Grant [number PET0009/2016]; and [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) #2] under Finance [Code 001].
dc.descriptionPoorly controlled diabetes mellitus leads to several comorbidities, including susceptibility to infections. Hyperglycemia increases phagocyte responsiveness, however immune cells from people with diabetes show inadequate antimicrobial functions. We and others have shown that aberrant production of leukotriene B4 (LTB4) is detrimental to host defense in models of bacterial infection. Here, we will unveil the consequences of high glucose in the outcome of Leishmania braziliensis skin infection in people with diabetes and determine the role of LTB4 in human phagocytes. We show that diabetes leads to higher systemic levels of LTB4, IL-6 and TNF-α in cutaneous leishmaniasis. Only LTB4 correlated with blood glucose levels and healing time in diabetes comorbidity. Skin lesions of people with leishmaniasis and diabetes exhibit increased neutrophil and amastigote numbers. Monocyte-derived macrophages from these individuals showed higher L. braziliensis loads, reduced production of Reactive Oxygen Species and unbalanced LTB4/PGE2 ratio. Our data reveal a systemic inflammation driven by diabetes comorbidity in opposition to a local reduced capacity to resolve L. braziliensis infection and a worse disease outcome.
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis Open
dc.rightsopen access
dc.subjectDiabetes
dc.subjectHuman leishmaniasis
dc.subjectLeishmania braziliensis
dc.subjectLipid mediators
dc.subjectLTB4
dc.subjectPGE2
dc.subjectDiabetes;
dc.subjectHuman leishmaniasis
dc.subjectLeishmania braziliensis
dc.subjectLipid mediators
dc.subjectLTB4
dc.subjectPGE2
dc.titleUnbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
dc.typeArticle


Este ítem pertenece a la siguiente institución