Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria

dc.creatorCosta, Allyson Guimarães
dc.creatorChaves, Yury Oliveira
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorRamasawmy, Rajendranath
dc.creatorAntonelli, Lis Ribeiro Valle
dc.creatorBarbosa, Lucas
dc.creatorBalieiro, Antonio
dc.creatorMonteiro, Wuelton Marcelo
dc.creatorMourão, Maria Paula
dc.creatorLacerda, Marcus Vinicius Guimarães
dc.creatorMartins Filho, Olindo Assis
dc.creatorCosta, Fabio Trindade Maranhão
dc.creatorMalheiro, Adriana
dc.creatorNogueira, Paulo Afonso
dc.date2020-08-17T18:46:23Z
dc.date2020-08-17T18:46:23Z
dc.date2020
dc.date.accessioned2023-09-26T20:22:19Z
dc.date.available2023-09-26T20:22:19Z
dc.identifierCOSTA, Allyson Guimarães et al. Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria. Mem. Inst. Oswaldo Cruz, Rio de Janeiro , v. 115, e200080, 2020
dc.identifier1678-8060
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42812
dc.identifier10.1590/0074-02760200080
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855386
dc.descriptionBACKGROUND: Thrombocytopenia in malaria involves platelet destruction and consumption; however, the cellular response underlying this phenomenon has still not been elucidated. OBJECTIVE: To find associations between platelet indices and unbalanced Th1/Th2/Th17 cytokines as a response to thrombocytopenia in Plasmodium vivax infected (Pv-MAL) patients. METHODS: Platelet counts and quantification of Th1/Th2/Th17 cytokine levels were compared in 77 patients with uncomplicated P. vivax malaria and 37 healthy donors from the same area (endemic control group - ENCG). FINDINGS: Thrombocytopenia was the main manifestation in 55 patients, but was not associated with parasitaemia. The Pv-MAL patients showed increases in the mean platelet volume (MPV), which may be consistent with larger or megaplatelets. Contrary to the findings regarding the endemic control group, MPV and platelet distribution width (PDW) did not show an inverse correlation, due the increase in the heterogeneity of platelet width. In addition, the Pv-MAL patients presented increased IL-1β and reduced IL-12p70 and IL-2 serum concentrations. Furthermore, the reduction of these cytokines was associated with PDW values. MAIN CONCLUSIONS: Our data demonstrate that an increase in MPV and the association between reductions of IL-2 and IL-12 and PDW values may be an immune response to thrombocytopenia in uncomplicated P. vivax malaria.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjectplatelet
dc.subjectPlasmodium vivax
dc.subjectIL-12p70
dc.subjectIL-2
dc.subjectIL-1 beta
dc.subjectthrombocytopenia
dc.titleIncreased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria
dc.typeArticle


Este ítem pertenece a la siguiente institución