Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?

dc.creatorPalma, Mariana L.
dc.creatorZamith-Miranda, Daniel
dc.creatorMartins, Flaviano S.
dc.creatorBozza, Fernando A.
dc.creatorNimrichter, Leonardo
dc.creatorMontero-Lomeli, Mônica
dc.creatorMarques, Ernesto T. A.
dc.creatorDouradinha, Bruno
dc.date2019-08-13T12:52:08Z
dc.date2019-08-13T12:52:08Z
dc.date2015
dc.date.accessioned2023-09-26T20:22:00Z
dc.date.available2023-09-26T20:22:00Z
dc.identifierPALMA, Mariana L. et al. Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement? Applied Microbiology and Biotechnology, v. 99, p. 6563-6570, 2015.
dc.identifier0175-7598
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34762
dc.identifier10.1007/s00253-015-6776-x
dc.identifier1432-0614
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855259
dc.descriptionThe probiotic yeast Saccharomyces cerevisiae var boulardii is widely used as a low cost and efficient adjuvant against gastrointestinal tract disorders such as inflammatory bowel disease and treatment of several types of diarrhea, both in humans and animals. S. boulardii exerts its protective mechanisms by binding and neutralizing enteric pathogens or their toxins, by reducing inflammation and by inducing the secretion of sIgA. Although several S. cerevisiae strains have proven probiotic potential in both humans and animals, only S. boulardii is currently licensed for use in humans. Recently, some researchers started using S. boulardii as heterologous protein expression systems. Combined with their probiotic activity, the use of these strains as prophylactic and therapeutic proteins carriers might result in a positive combined effort to fight specific diseases. Here, we provide an overview of the current use of S. cerevisiae strains as probiotics and their mechanisms of action. We also discuss their potential to produce molecules with biotherapeutic application and the advantages and hurdles of this approach. Finally, we suggest future directions and alternatives for which the combined effort of specific immunomodulatory effects of probiotic S. cerevisiae strains and ability to express desired foreign genes would find a practical application.
dc.description2020-08-13
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectProbiotics
dc.subjectSaccharomyces cerevisiae
dc.subjectSaccharomyces cerevisiae var boulardii
dc.subjectMechanisms of action
dc.subjectExpression of heterologous proteins
dc.titleProbiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
dc.typeArticle


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