Prevalence and level of antibodies to the circumsporozoite protein of human malaria parasites in five states of the Amazon region of Brazil

dc.creatorArruda, Mércia E.
dc.creatorZimmerman, Robert H.
dc.creatorSouza, Renata M. C.
dc.creatorFerreira, Joseli Oliveira
dc.date2020-11-22T18:58:47Z
dc.date2020-11-22T18:58:47Z
dc.date2007
dc.date.accessioned2023-09-26T20:21:37Z
dc.date.available2023-09-26T20:21:37Z
dc.identifierARRUDA, Mercia E. et al. Prevalence and level of antibodies to the circumsporozoite protein of human malaria parasites in five states of the Amazon region of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 367-371, June 2007.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44575
dc.identifier10.1590/S0074-02762007005000041
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855095
dc.descriptionThe aim of this study was to determine the prevalence of malaria infection and antibodies against the repetitive epitopes of the circumsporozoite (CS) proteins of Plasmodium falciparum, P. malariae, P. vivax VK210, P. vivax VK247, and P. vivax-like in individuals living in the states of Rondônia, Pará, Mato Grosso, Amazonas, and Acre. Active malaria transmission was occurring in all studied sites, except in Acre. P. falciparum was the predominant species in Pará and Rondônia and P. vivax in Mato Grosso. Infection by P. malariae was low but this Plasmodium species was detected in Rondônia (3.5%), Mato Grosso (2.5%), and Pará (0.8%). High prevalence and levels of serological reactivity against the CS repeat peptides of P. falciparum were detected in Rondônia (93%) and Pará (85%). Sera containing antibodies against the CS repeat of P. malariae occurred more frequently in Rondônia (79%), Pará (76%), and Amazonas (68%). Antibodies against the repeat epitope of the standard CS protein of P. vivax VK210, P. vivax VK247, and P. vivax-like were more frequent in Rondônia, Pará, and Mato Grosso. The high frequency of reactions to P. malariae in most of the areas suggests that the infection by this Plasmodium species has been underestimated in Brazil.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectPlasmodium
dc.subjectInfecção
dc.subjectRegião Amazônica
dc.subjectBrasil
dc.subjectPlasmodium
dc.subjectInfection
dc.subjectAmazon region
dc.subjectBrazil
dc.titlePrevalence and level of antibodies to the circumsporozoite protein of human malaria parasites in five states of the Amazon region of Brazil
dc.typeArticle


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