Advanced glycation end product: A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study

dc.creatorPereira, Evelyn Nunes Goulart da Silva
dc.creatorPaula, Daniela Polessa
dc.creatorAraujo, Beatriz Peres de
dc.creatorFonseca, Maria de Jesus Mendes da
dc.creatorDiniz, Maria de Fátima Haueisen Sander
dc.creatorDaliry, Anissa
dc.creatorGriep, Rosane Harter
dc.date2021-09-05T18:52:06Z
dc.date2021-09-05T18:52:06Z
dc.date2021
dc.date.accessioned2023-09-26T20:21:35Z
dc.date.available2023-09-26T20:21:35Z
dc.identifierPEREIRA, Evelyn Nunes Goulart da Silva et al. Advanced glycation end product: A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study. World Journal of Gastroenterology, v. 27, n. 29, p. 4913-4928, Aug. 2021.
dc.identifier1007-9327
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48992
dc.identifier10.3748/wjg.v27.i29.4913
dc.identifier2219-2840
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855080
dc.descriptionBACKGROUND Liver diseases are associated with the excess formation of advanced glycation end products (AGEs), which induce tissue inflammation and oxidative damage. However, the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease (NAFLD) is unclear. AIM To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil population. METHODS In 305 individuals at baseline ELSA-Brasil, NAFLD-associated steatosis was classified by ultrasound hepatic attenuation. The participants were grouped according to the severity of steatosis: mild and moderate/severe pooled. The measurement of serum fluorescent AGE concentrations was based on spectro fluorimetric detection. Serum AGE content and clinical and laboratory character istics of the participants were compared between groups. The correlation between serum AGE levels and the grade of steatosis was analyzed. Logistic regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity. A P value < 0.05 was considered statistically significant.
dc.formatapplication/pdf
dc.languageeng
dc.publisherF6Publishing
dc.rightsopen access
dc.subjectProdutos finais de glicação avançada
dc.subjectDoença hepática gordurosa não alcoólica
dc.subjectEsteatose
dc.subjectEstudo ELSA-Brasil
dc.subjectEspectroscopia
dc.subjectAdvanced glycation end products
dc.subjectNon-alcoholic fatty liver disease
dc.subjectSteatosis
dc.subjectELSA-Brasil study
dc.subjectSpectroscopy
dc.titleAdvanced glycation end product: A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study
dc.typeArticle


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