Constituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities

dc.creatorAraújo, Clinascia Rodrigues Rocha
dc.creatorSilva, Roqueline Rodrigues
dc.creatorSilva, Thiago de Melo
dc.creatorTakahashi, Jacqueline Aparecida
dc.creatorSales Junior, Policarpo Ademar
dc.creatorPinto, Nisia Andrade Villela Dessimoni
dc.creatorFagundes, Elaine Maria de Souza
dc.creatorRomanha, Alvaro José
dc.creatorMurta, Silvane Maria Fonseca
dc.creatorAlcântara, Antônio Flávio de Carvalho
dc.date2019-08-07T13:44:21Z
dc.date2019-08-07T13:44:21Z
dc.date2017
dc.date.accessioned2023-09-26T20:21:25Z
dc.date.available2023-09-26T20:21:25Z
dc.identifierARAÚJO, Clinascia Rodrigues Rocha et al. Constituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities. Natural Product Research, v. 31, n. 16, p. 1948-1953, 2017.
dc.identifier1478-6419
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34649
dc.identifier10.1080/14786419.2016.1266346
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855017
dc.descriptionLuehea species are found in almost all Central and South American countries. The present work describes the phytochemical study, isolation, and structural characterisation of friedelin, β-friedelinol, lupeol, pseudotaraxasterol, β-sitosterol, betulinic acid, taraxasterol, (-)-epicatechin, β-sitosterol-3-O-β-d-glucopyranoside, and (+)-epicatechin-(4β→8)-epicatechin from stem barks of Luehea ochrophylla Mart. The structural identification of the isolated compounds was mainly performed by NMR analyses and comparison with the data from literature. These compounds were isolated for the first time in the genus Luehea, except β-sitosterol glucopyranoside, (-)-epicatechin, and lupeol. Hexane extract (HE) and dichloromethane (DF) and ethyl acetate (AF) fractions exhibited antiparasitic activity against amastigote (intracellular) and trypomastigote culture forms of Trypanosoma cruzi. The ethanol extract (EE), DF, and ethanol fraction (EF) exhibited considerable antifungal activity against Candida albicans. Moreover, extracts and fractions exhibited significant percentage of capture free radicals of 2,2-diphenyl-picrylhydrazyl (DPPH) when compared to the standard of ascorbic acid.
dc.description2100-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis Health Sciences
dc.rightsrestricted access
dc.subjectLuehea ochrophylla
dc.subjectAntimicrobial action
dc.subjectAntioxidant activity
dc.subjectAntiparasitic activity
dc.titleConstituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities
dc.typeArticle


Este ítem pertenece a la siguiente institución