Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome

dc.creatorLeite, Pauline Martins
dc.creatorGomes, Rodrigo Saar
dc.creatorFigueiredo, Amanda Braga de
dc.creatorSerafim, Tiago Donatelli
dc.creatorMoura, Sandra Aparecida Lima de
dc.creatorAfonso, Luís Carlos Crocco
dc.creatorTafuri, Wagner Luiz
dc.creatorSouza, Carolina Carvalho de
dc.creatorFietto, Juliana Lopes Rangel
dc.creatorMelo, Maria Norma
dc.creatorDias, Fátima Ribeiro
dc.creatorOliveira, Milton Adriano Pelli de
dc.creatorRabello, Ana Lúcia Teles
dc.date2014-05-23T16:11:22Z
dc.date2014-05-23T16:11:22Z
dc.date2012
dc.date.accessioned2023-09-26T20:21:24Z
dc.date.available2023-09-26T20:21:24Z
dc.identifierLEITE, Pauline Martins et al. Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome. Plos Neglected Tropical Diseases. 2012, vol.6, pp. e1850
dc.identifier1935-2735
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7646
dc.identifier10.1371/journal.pntd.0001850
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855011
dc.descriptionCutaneous leishmaniasis is a widespread tropical disease caused by different species of Leishmania protozoa that are transmitted by infected sandflies. Clinical presentations are extremely diverse and dependent on a variety of parasite and host factors that are poorly understood. Leishmania (V.) braziliensis infection may result in a devastating disease manifestation characterized by the development of destructive lesions in the oral, nasal, and pharyngeal mucosal. Ecto-nucleotidases are enzymes that are involved in the hydrolysis of extracellular nucleotides. These enzymes have been shown to correlate with virulence of Leishmania parasites. In this work, we evaluated the ecto-nucleotidase activity of promastigotes from the twenty three different L. braziliensis isolates. We demonstrated that isolates obtained from mucosal lesions present higher levels of ecto-nucleotidase activity than those from cutaneous lesions. In addition, we show that in the murine model of cutaneous leishmaniasis, promastigote forms of parasite with higher activity induce a delayed/decreased immune response that may correlate with spreading of the parasites throughout the body. Thus, we propose that the level of ecto-nucleotidase activity of promastigotes may be a marker for the development of severe clinical forms of cutaneous leishmaniasis and also a possible target for future therapeutic intervention.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectPromastigote
dc.subjectLeishmania
dc.subjectParasites/Research
dc.subjectDisease/progression
dc.subjectParasitism
dc.titleEcto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
dc.typeArticle


Este ítem pertenece a la siguiente institución