Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi

dc.creatorSouza, E. M. de
dc.creatorMenna-Barreto, Rubem F.S.
dc.creatorAraujo-Jorge, Tania C.
dc.creatorKumar, A.
dc.creatorHu, Q.
dc.creatorBoykin, D. W.
dc.creatorSoeiro, Maria Nazaré C.
dc.date2020-02-04T14:00:48Z
dc.date2020-02-04T14:00:48Z
dc.date2006
dc.date.accessioned2023-09-26T20:21:24Z
dc.date.available2023-09-26T20:21:24Z
dc.identifierSOUZA, E. M. de et al. Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi. Parasitology, v. 133, p. 75-79, 2006.
dc.identifier0031-1820
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39708
dc.identifier10.1017/S0031182006000084
dc.identifier1469-8161
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8855010
dc.descriptionTwo aromatic diamidines, furamidine (DB75) and its phenyl-substituted analogue (DB569), which exhibit trypanocidal activity, were assayed against Trypanosoma cruzi and were found to induce apoptosis-like death characteristics such as nuclear DNA condensation and fragmentation, decreased mitochondrial membrane potential and phosphatidylserine exposure. DB569 displays superior trypanocidal activity compared to furamidine and also had higher ability to induce apoptosis-like death in treated parasites. The present results showing apoptosis-like death in T. cruzi after treatment with both DB75 and DB569 make important contributions to the understanding of the mechanisms of the aromatic diamidines, which represent promising trypanocidal compounds.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherCambridge University Press
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectCompostos tripanocidas
dc.subjectDiamidinas aromáticas
dc.subjectAromatic diamidines
dc.subjectTrypanosoma cruzi
dc.subjectApoptosis-like death
dc.subjectTrypanocidal compounds
dc.titleAntiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi
dc.typeArticle


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