In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni

dc.creatorMatos-Rocha, Thiago José
dc.creatorCavalcanti, Marília Gabriela dos Santos
dc.creatorBarbosa-Filho, José Maria
dc.creatorLúcio, Ana Silvia Suassuna Carneiro
dc.creatorVeras, Dyana Leal
dc.creatorFeitosa, Ana Paula Sampaio
dc.creatorSiqueira Júnior, José Pinto de
dc.creatorAlmeida, Reinaldo Nóbrega de
dc.creatorMarques, Márcia Ortiz Mayo
dc.creatorAlves, Luiz Carlos
dc.creatorBrayner, Fábio André
dc.date2018-03-28T14:32:39Z
dc.date2018-03-28T14:32:39Z
dc.date2013
dc.date.accessioned2023-09-26T20:21:04Z
dc.date.available2023-09-26T20:21:04Z
dc.identifierMATOS-ROCHA, T. J. et al. In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni. Planta Medica, v. 79, n. 14, p. 1307–1312, set. 2013.
dc.identifier1439-0221
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25544
dc.identifier10.1055/s-0033-1350732
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854884
dc.descriptionLTF / UFPB, ao LIKA / UFPE e à FIOCRUZ-PE pelo apoio aos experimentos e à CAPES por uma bolsa de estudos.
dc.descriptionThis study aimed to determine the composition of the essential oil of Mentha x villosa and to evaluate its biological effects in vitro on adult worms of S. mansoni. Rotundifolone (70.96 %), limonene (8.75 %), trans-caryophyllene (1.46 %), and β-pinene (0.81 %) were shown to be the major constituents of this oil. Adult worms of S. mansoni were incubated with different concentrations of the essential oil (1, 10, 100, 250, 500, and 1000 µg/mL) and of its constituents rotundifolone (0.7, 3.54, 7.09, 70.96, 177.4, 354.8, and 700.96 µg/mL), limonene (43.75 µg/mL), trans-caryophyllene (7.3 µg/mL), and β-pinene (4.03 µg/mL). No schistosomicidal activity was identified at the trans-caryophyllene and β-pinene concentrations studied. However, use of the essential oil (10 µg/mL), rotundifolone (7.09 µg/mL), and limonene (43.75 µg/mL) resulted in decreased worm motility continuing until 96 hours of observation. At higher concentrations (100 and 70.96 µg/mL, respectively), both the essential oil and rotundifolone caused mortality among adult worms of S. mansoni. The positive control praziquantel caused the death of all parasites after 24 h of evaluation. The results from this study suggest that the essential oil of Mentha x villosa presents schistosomicidal efficacy.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectLamiaceae
dc.subjectMentha x villosa
dc.subjectSchistosoma mansoni
dc.subjectAtividade esquistossomicida
dc.subjectProdutos naturais
dc.subjectLamiaceae
dc.subjectMentha x villosa
dc.subjectSchistosoma mansoni
dc.subjectSchistosomicidal activity
dc.subjectNatural products
dc.subjectAnimais
dc.subjectCompostos bicíclicos em ponte / análise
dc.subjectCompostos bicíclicos em ponte / farmacologia
dc.subjectCiclohexenos / análise
dc.subjectCiclohexenos / farmacologia
dc.subjectMentha / química
dc.subjectMonoterpenos / análise
dc.subjectMonoterpenos / farmacologia
dc.subjectÓleos voláteis / química
dc.subjectÓleos Voláteis / Farmacêuticos
dc.subjectExtratos Vegetais / química
dc.subjectExtratos Vegetais / Farmacologia
dc.subjectSchistosoma mansoni / efeitos de drogas
dc.subjectEsquistossomicidas / farmacologia
dc.subjectSesquiterpenos / análise
dc.subjectSesquiterpenos / farmacologia
dc.subjectTerpenos / análise
dc.subjectTerpenos / farmacologia
dc.titleIn vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni
dc.typeArticle


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