Studies on the activation of the pre-kininogenin-kininogenin (pre-kallikrein-kallikrein) system by sulfated polysaccharides and kaolin

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatordos Santos, E.
dc.creatorRothschild, Hanna A.
dc.creatorRocha e Silva, M.
dc.date2014-05-26T16:49:49Z
dc.date2016-10-25T18:11:30Z
dc.date2014-05-26T16:49:49Z
dc.date2016-10-25T18:11:30Z
dc.date1979-12-01
dc.date.accessioned2017-04-06T00:38:49Z
dc.date.available2017-04-06T00:38:49Z
dc.identifierAdvances in the Biosciences, v. 17, n. C, p. 145-150, 1979.
dc.identifier0065-3446
dc.identifierhttp://hdl.handle.net/11449/63468
dc.identifierhttp://acervodigital.unesp.br/handle/11449/63468
dc.identifier2-s2.0-0018274975
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/885483
dc.descriptionThe activation of pre-kininogenin to kininogenin (pre-kallikrein to kallikrein) is one of the steps in the series of reactions of a complex system, linked also to fibrinolysis and coagulation, that leads to kinin release in plasma (See Cochrane et al., 1976; Wuepper, 1976; Kaplan et al., 1976; Kaplan et al., 1976). For human plasma, a test using kaolin as activator and measuring kallikrein activity with the chromogenic substrate Chromozym PK (Nα-benzoyl-prolyl-phenylalanyl-arginyl-nitroanilide, Pentapharm, Basle) is routinely employed. The purpose of this paper is to further study the mechanism of this activation, by means of different activators and using as inhibitor hexadimethrine bromide (Polybrene). Besides kaolin, sulfated polysaccharides, such as heparin and cellulose sulfate are able to activate pre-kininogenin to kininogenin. Hexadimethrine as expected, inhibited the activation by heparin and also that by cellulose sulfate. The activation by kaolin however followed a different pattern suggesting, at least partially, a different mode of action of this activator. © 1979.
dc.languageeng
dc.relationAdvances in the Biosciences
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcellulose
dc.subjectdrug derivative
dc.subjectheparin
dc.subjectkallikrein
dc.subjectkaolin
dc.subjectprekallikrein
dc.subjectsulfuric acid
dc.subjectanimal
dc.subjectenzyme activation
dc.subjectmetabolism
dc.subjectrat
dc.subjectAnimal
dc.subjectCellulose
dc.subjectEnzyme Activation
dc.subjectHeparin
dc.subjectKallikreins
dc.subjectKaolin
dc.subjectPrekallikrein
dc.subjectRats
dc.subjectSulfuric Acids
dc.titleStudies on the activation of the pre-kininogenin-kininogenin (pre-kallikrein-kallikrein) system by sulfated polysaccharides and kaolin
dc.typeOtro


Este ítem pertenece a la siguiente institución