Co-infection of human herpesvirus type 2 (HHV-2) and human immunodeficiency virus (HIV) among pregnant women in Rio de Janeiro, Brazil

dc.creatorLima, Lyana Rodrigues Pinto
dc.creatorFernandes, Luis Eduardo Barros Costa
dc.creatorVillela, Daniel A. M.
dc.creatorMorgado, Mariza Gonçalves
dc.creatorPilotto, José Henrique
dc.creatorPaula, Vanessa Salete de
dc.date2019-02-19T11:45:56Z
dc.date2019-02-19T11:45:56Z
dc.date2018
dc.date.accessioned2023-09-26T20:20:56Z
dc.date.available2023-09-26T20:20:56Z
dc.identifierLIMA, Lyana Rodrigues Pinto et al. Co-infection of human herpesvirus type 2 (HHV-2) and human immunodeficiency virus (HIV) among pregnant women in Rio de Janeiro, Brazil. Aids Care, v. 30, n. 3, p. 378-382, 2018.
dc.identifier0954-0121
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31729
dc.identifier10.1080/09540121.2017.1378798
dc.identifier1360-0451
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854831
dc.descriptionPregnant women who are infected with the Human Immunodeficiency Virus (HIV) are particularly vulnerable to severe and recurrent infections with Human Herpesvirus 2 (HHV-2). Neonatal transmission of HHV-2 has been associated with malformations and neurological sequelae in infants, which makes it very important to perform antenatal monitoring for genital herpes. In the study, 134 pregnant women infected with HIV were tested for HHV-2 IgM and IgG using an enzyme-linked immunosorbent assay (ELISA) and had HHV-2 DNA analyzed by Real Time Polymerase Chain Reaction (qPCR). Fisher's exact test was applied to analyze the epidemiological dates (p < 0.05). A total of 59.7% of the pregnant women infected with HIV had HHV-2 IgG and 3.75% of them showed HHV-2 viremia. HHV-2 IgM was found in 6% of the pregnant women and 25% of them had HHV-2 viremia. The risk factors associated with HHV-2 seropositive were age under 20 and a CD4/CD8 ratio > 1. Our study found high HHV-2/HIV coinfection prevalence and HHV-2 viremia among patients with recurrent and primary genital infection, reinforcing the need of prevention and control of HHV-2 infection in order to avoid this virus transmission.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsrestricted access
dc.subjectMulheres grávidas
dc.subjectCo-infecção
dc.subjectHIV
dc.subjectHerpesvirus Humano 2
dc.subjectRio de Janeiro
dc.subjectCoinfection
dc.subjectPregnant women
dc.subjectHIV
dc.subjectHHV-2
dc.subjectHSV-2
dc.subjectRio de Janeiro
dc.titleCo-infection of human herpesvirus type 2 (HHV-2) and human immunodeficiency virus (HIV) among pregnant women in Rio de Janeiro, Brazil
dc.typeArticle


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