Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil

dc.creatorCartaxo, Marina F. S.
dc.creatorAyres, Constância F. J.
dc.creatorWeetman, David
dc.date2018-04-20T13:23:57Z
dc.date2018-04-20T13:23:57Z
dc.date2011
dc.date.accessioned2023-09-26T20:20:30Z
dc.date.available2023-09-26T20:20:30Z
dc.identifierCARTAXO, M. F. S.; AYRES, C. F. J.; WEETMAN, D. Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 9, p. 491–499, set. 2011.
dc.identifier1878-3503
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25977
dc.identifier10.1016/j.trstmh.2011.05.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854659
dc.descriptionEste projeto foi financiado pela Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE) APQ0060-2.02 / 07.
dc.descriptionRecife is one of the largest cities in north-eastern Brazil and is endemic for lymphatic filariasis transmitted by Culex quinquefasciatus. Since 2003 a control program has targeted mosquito larvae by elimination of breeding sites and bimonthly application of Bacillus sphaericus. To assess the impact of this program on the local vector population we monitored the genetic diversity and differentiation of Cx. quinquefasciatus using microsatellites and a B. sphaericus-resistance associated mutation (cqm1(REC)) over a 3-year period. We detected a significant but gradual decline in allelic diversity, which, coupled with subtle temporal genetic structure, suggests a major impact of the control program on the vector population. Selection on cqm1(REC) does not appear to be involved with loss of neutral diversity from the population, with no temporal trend in resistant allele frequency and no correlation with microsatellite differentiation. The evidence for short-term genetic drift we detected suggests a low ratio of effective population size: census population size for Cx. quinquefasciatus, perhaps coupled with strong geographically-restricted population structure. Spatial definition of populations will be an important step for success of an expanded vector control program.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectCulex quinquefasciatus
dc.subjectBacillus sphaericus
dc.subjectFilariose linfática
dc.subjectMicrossatélites
dc.subjectDesvio genético
dc.subjectGene receptor cqm1
dc.subjectCulex quinquefasciatus
dc.subjectBacillus sphaericus
dc.subjectLymphatic filariasis
dc.subjectMicrosatellite
dc.subjectGenetic drift
dc.subjectReceptor gene cqm1
dc.subjectAnimais
dc.subjectBrasil / epidemiologia
dc.subjectCulex / genética
dc.subjectFilariose Linfática / epidemiologia
dc.subjectElefantíase, filarial / prevenção & controle
dc.subjectFreqüência Genética
dc.subjectDeriva Genética
dc.subjectVariação genética
dc.subjectHumanos
dc.subjectRepetições de Microssatélites
dc.subjectControle de Mosquito
dc.subjectMutação
dc.subjectDensidade populacional
dc.titleLoss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil
dc.typeArticle


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