COVID-19: molecular targets, drug repurposing and new avenues for drug discovery

dc.creatorSenger, Mario Roberto
dc.creatorEvangelista, Tereza Cristina Santos
dc.creatorDantas, Rafael Ferreira
dc.creatorSantana, Marcos Vinicius da Silva
dc.creatorGonçalves, Luiz Carlos Saramago
dc.creatorSouza Neto, Lauro Ribeiro de
dc.creatorFerreira, Sabrina Baptista
dc.creatorSilva Junior, Floriano Paes
dc.date2020-10-05T18:22:56Z
dc.date2020-10-05T18:22:56Z
dc.date2020
dc.date.accessioned2023-09-26T20:20:24Z
dc.date.available2023-09-26T20:20:24Z
dc.identifierSENGER, Mario Roberto et al. COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p.1-32, Oct. 2020.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/43817
dc.identifier10.1590/0074-02760200254
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854621
dc.descriptionCoronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectReposição de drogas
dc.subjectDescoberta de drogas
dc.subjectCiclo de replicação
dc.subjectAlvos de drogas
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectDrug repurposing
dc.subjectDrug discovery
dc.subjectReplication cycle
dc.subjectDrug targets
dc.titleCOVID-19: molecular targets, drug repurposing and new avenues for drug discovery
dc.typeArticle


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