Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents.

dc.creatorInam, Afreen
dc.creatorSiddiqui, Shadab Miyan
dc.creatorMacedo, Taís Soares
dc.creatorMoreira, Diogo Rodrigo Magalhães
dc.creatorLeite, Ana Cristina Lima
dc.creatorSoares, Milena Botelho Pereira
dc.creatorAzam, Amir
dc.date2014-09-26T16:57:39Z
dc.date2014-09-26T16:57:39Z
dc.date2014
dc.date.accessioned2023-09-26T20:20:17Z
dc.date.available2023-09-26T20:20:17Z
dc.identifierINAM, A. et al. Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents. European Journal of Medicinal Chemistry, v. 75, p. 67-76, 2014.
dc.identifier1768-3254
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8459
dc.identifier10.1016/j.ejmech.2014.01.023
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854581
dc.descriptionN-Acylhydrazones derived from 7-chloro-4-piperazin-1-yl-quinoline were synthesized and biologically evaluated for blood-stage of Plasmodium falciparum and Entamoeba histolytica trophozoites. N-Acylhydrazone F12 was found to inhibit the P. falciparum growth as well as its life cycle with good selectivity, which was achieved by inhibiting hematin formation. Compound F24 showed better IC50 value than the amoebicidal drug metronidazole
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Masson SAS
dc.rightsopen access
dc.subjectMalaria
dc.subjectAmoebiasis
dc.subjectAminoquinoline
dc.subjectPiperazinyl derivatives
dc.subjectAcylhydrazone
dc.titleDesign, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents.
dc.typeArticle


Este ítem pertenece a la siguiente institución