Fasting, adrenalectomy, and gluconeogenesis in the chicken and a carnivorous bird

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorVeiga, J. A. S.
dc.creatorRoselino, E. S.
dc.creatorMigliorini, R. H.
dc.date2014-05-26T15:32:44Z
dc.date2016-10-25T18:11:26Z
dc.date2014-05-26T15:32:44Z
dc.date2016-10-25T18:11:26Z
dc.date1978-12-01
dc.date.accessioned2017-04-06T00:38:32Z
dc.date.available2017-04-06T00:38:32Z
dc.identifierAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 3, n. 2, 1978.
dc.identifier0363-6119
dc.identifierhttp://hdl.handle.net/11449/63429
dc.identifierhttp://acervodigital.unesp.br/handle/11449/63429
dc.identifier2-s2.0-0018224845
dc.identifierhttp://ajpregu.physiology.org/content/234/3/R115
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/885446
dc.descriptionPrevious studies showed that livers from carnivorous birds have a higher gluconeogenic capacity and higher levels of gluconeogenic enzymes than livers from granivorous birds. In this work we compare the effects of fasting and adrenalectomy on gluconeogenesis. Fasting in the chicken elicited increased rates of incorporation of 14C from alanine into blood glucose, increased gluconeogenesis in liver slices, and increased activities of four gluconeogenic enzymes: glucose-6-phosphatase, phosphoenolpyruvate carboxykinase, alanine aminotransferase, and aspartate aminotransferase. These responses in the chicken resemble those observed in fasted rodents. In marked contrast, fasting in black vultures induced decreased rates of incorporation of alanine label into circulating glucose, decreased gluconeogenesis in liver slices, and no change in any of the four enzymes studied. This unusual response to fasting in the carnivorous bird is probably related to the high-protein-low-carbohydrate content of the diet. Fasted adrenalectomized birds (granivorous and carnivorous) had reduced rates of in vivo glucose synthesis, decreased liver gluconeogenesis, and lower activity of glucose-6-phosphatase and aspartate aminotransferase, without change in phosphoenolpyruvate carboxykinase and alanine aminotransferase activities.
dc.languageeng
dc.relationAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectaspartate aminotransferase
dc.subjectglucose 6 phosphate
dc.subjectphosphopyruvate carboxylase
dc.subjectadrenalectomy
dc.subjectalanine c 14
dc.subjectanimal experiment
dc.subjectbird
dc.subjectcaloric restriction
dc.subjectchicken
dc.subjectendocrine system
dc.subjectgluconeogenesis
dc.subjectliver slice
dc.subjectsmall intestine
dc.titleFasting, adrenalectomy, and gluconeogenesis in the chicken and a carnivorous bird
dc.typeOtro


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