Chlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission

dc.creatorAdachi, Kristina
dc.creatorKlausner, Jeffrey D.
dc.creatorBristow, Claire C.
dc.creatorXu, Jiahong
dc.creatorAnk, Bonnie
dc.creatorMorgado, Mariza G.
dc.creatorWatts, D. Heather
dc.creatorWeir, Fred
dc.creatorPersing, David
dc.creatorMofenson, Lynne M.
dc.creatorVeloso, Valdiléa G.
dc.creatorPilotto, José Henrique
dc.creatorJoão, Esau
dc.creatorNielsen-Saines, Karin
dc.date2016-07-07T11:36:52Z
dc.date2016-07-08T18:49:08Z
dc.date2016-07-07T11:36:52Z
dc.date2016-07-08T18:49:08Z
dc.date2015
dc.date.accessioned2023-09-26T20:19:56Z
dc.date.available2023-09-26T20:19:56Z
dc.identifierADACHI, Kristina; et al. Chlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission. Sexually Transmitted Diseases, v.42, n.10, p.554-565, Oct. 2015.
dc.identifier0148-5717
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/14805
dc.identifier10.1097/OLQ.0000000000000340
dc.identifier1537-4521
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854439
dc.descriptionBackground: Sexually transmitted infections (STIs) such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) can lead to adverse pregnancy and neonatal outcomes. The prevalence of STIs and its association with HIV mother-to-child transmission (MTCT) were evaluated in a substudy analysis from a randomized, multicenter clinical trial. Methodology: Urine samples from HIV-infected pregnant women collected at the time of labor and delivery were tested using polymerase chain reaction testing for the detection of CT and NG (Xpert CT/NG; Cepheid, Sunnyvale, CA). Infant HIV infection was determined by HIV DNA polymerase chain reaction at 3 months. Results: Of the 1373 urine specimens, 249 (18.1%) were positive for CT and 63 (4.6%) for NG; 35 (2.5%) had both CT and NG detected. Among 117 cases of HIV MTCT (8.5% transmission), the lowest transmission rate occurred among infants born to CT- and NG-uninfected mothers (8.1%) as compared with those infected with only CT (10.7%) and both CT and NG (14.3%; P = 0.04). Infants born to CT-infected mothers had almost a 1.5- fold increased risk for HIV acquisition (odds ratio, 1.47; 95% confidence interval, 0.9–2.3; P = 0.09). Conclusions: This cohort of HIV-infected pregnant women is at high risk for infection with CT and NG. Analysis suggests that STIs may predispose to an increased HIV MTCT risk in this high-risk cohort of HIVinfected women.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsrestricted access
dc.subjectClamídia
dc.subjectGonorréia
dc.subjectGrávidas infectadas com o VIH
dc.subjectTransmissão infantil do HIV
dc.subjectChlamydia
dc.subjectGonorrhea
dc.subjectHIV-Infected Pregnant Women
dc.subjectInfant HIV Transmission
dc.titleChlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission
dc.typeArticle


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