In good company: association between fungal glycans generates molecular complexes with unique functions

dc.creatorRodrigues, Marcio Lourenço
dc.creatorNimrichter, Leonardo
dc.date2018-07-26T18:00:26Z
dc.date2018-07-26T18:00:26Z
dc.date2012
dc.date.accessioned2023-09-26T20:19:45Z
dc.date.available2023-09-26T20:19:45Z
dc.identifierRODRIGUES, Marcio L.; NIMRICHTER, Leonardo. In good company: association between fungal glycans generates molecular complexes with unique functions. Frontiers in Microbiology, v. 3, p. 1-5, July 2012.
dc.identifier1664-302X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27681
dc.identifier10.3389/fmicb.2012.00249
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854360
dc.descriptionThe biological properties of fungal immunogens have historically utilized testing of isolated molecules. Recent findings, however, indicate that fungal glycans differing in structure and function can interact to form hybrid complexes with unique properties. In the pathogenic yeast Cryptococcus neoformans, chitin-like molecules associate with capsular glucuronoxylomannan (GXM) to form functionally distinct glycan complexes. Such interactions between glycans that result in the formation of structures with different functions strongly suggest that additional molecular complexes with unknown properties may exist in fungal pathogens. Moreover, the identification of these novel complexes has stimulated the search of new immunogens with potential to protect human and animal hosts against systemic mycoses.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.rightsopen access
dc.subjectCryptococcus neoformans
dc.subjectDlucuronoxylomannan
dc.subjectPolysaccharides
dc.subjectGlycan association
dc.titleIn good company: association between fungal glycans generates molecular complexes with unique functions
dc.typeArticle


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