Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients

dc.creatorSantos, Wendell Vilas Boas
dc.creatorCerqueira, Bruno Antonio Veloso
dc.creatorZanette, Angela Maria Dias
dc.creatorReis, Mitermayer Galvão dos
dc.creatorBarral Netto, Manoel
dc.creatorGonçalves, Marilda de Souza
dc.date2011-04-06T13:50:55Z
dc.date2011-04-06T13:50:55Z
dc.date2010
dc.date.accessioned2023-09-26T20:19:41Z
dc.date.available2023-09-26T20:19:41Z
dc.identifierSANTOS, Wendell Vilas Boas et al. Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients. Annals of Hematology, v. 89, n. 9, p. 877-882, 2010.
dc.identifier1432-0584
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/1868
dc.identifier10.1007/s00277-010-0954-9
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854335
dc.descriptionSickle cell anemia (SCA) is characterized by a marked endothelial dysfunction, owing to many factors. Arginine metabolism can be related to the inflammatory chronic state presented by patients, playing a key role in their clinical outcome and vascular endothelium. We investigated the serum arginase levels in 50 SCA patients (22 men and 28 women, mean age of 17 +/- 10.5 years) and 28 healthy controls. Serum arginase levels were associated with biochemical hemolysis markers and cytokines involved in Th17 response, as well as levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1). Arginase concentrations were higher in SCA patients, compared with controls (p = 0.005), and were significantly and positively associated with total bilirubin (p = 0.004), indirect bilirubin (p = 0.04), and aspartate aminotransferase (AST; p = 0.039) in the SCA patient group. Moreover, arginase was significantly and positively associated with transforming growth factor-beta (TGF-beta; p = 0.008) among SCA patients. sICAM-1 was significantly and positively associated to reticulocytes (p = 0.014) and AST (p = 0.04). sVCAM-1 was likewise associated with lactate dehydrogenase (p = 0.03). These data suggest a new insight into arginase metabolism, as we show here a shift in arginine catabolism, where TGF-beta may induces the arginase pathway instead of the nitric oxide pathway and a possible involvement of the vascular activation and the serum arginase in chronic hemolysis among SCA patients. Additional studies should be carried out in order to investigate the mechanisms by which TGF-beta participates in the metabolism of arginase in SCA patients.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSickle cell anemia
dc.subjectArginine
dc.subjectArginase
dc.subjectTh17 cells
dc.subjectSoluble adhesion molecules
dc.subjectTGF-Beta
dc.subjectAnemia Falciforme
dc.subjectMolécula 1 de Adesão Intercelular
dc.subjectInterleucina-17
dc.subjectLinfócitos T Auxiliares-Indutores/ME
dc.subjectMolécula 1 de Adesão de Célula Vascular
dc.titleArginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
dc.typeArticle


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