| dc.creator | Ferreira, Leonardo Gomes Braga | |
| dc.creator | Faria, Juliana Vieira | |
| dc.creator | Santos, Juliana Pimenta Salles dos | |
| dc.creator | Faria, Robson Xavier | |
| dc.date | 2021-02-19T20:17:01Z | |
| dc.date | 2021-02-19T20:17:01Z | |
| dc.date | 2020 | |
| dc.date.accessioned | 2023-09-26T20:19:40Z | |
| dc.date.available | 2023-09-26T20:19:40Z | |
| dc.identifier | FERREIRA. Leonardo Gomes Braga et al. Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities. European Journal of Pharmacology, v. 887, p. 1-9, Aug. 2020. | |
| dc.identifier | 0014-2999 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/46116 | |
| dc.identifier | 10.1016/j.ejphar.2020.173356 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8854330 | |
| dc.description | Capsaicin (CAP) is a spice-derived substance of the genus Capsicum, which has high pungency and therapeutic
potential. For many years, it has been considered only as an agonist of the transient receptor potential vanilloid
member 1 (TRPV1), a member from the family of transient potential receptors (TRPs). Capsaicin can lead to a
variety of effects on cells, acting in specific organelles, and promoting different responses. Such studies, however,
point the capsaicin acting independently of the TRPV1 channel, being able to alter membrane fluidity, ion flux,
and reactive oxygen species levels on cells. In this context, capsaicin has been used as a therapeutic alternative
for the treatment of some diseases, such as disorders related to pain and inflammation. Further, researchers have
investigated the involvement of capsaicin in cancer. Thus, this review aims to examine the ways that capsaicin
can act on cells independently of the vanilloid receptor activation and demonstrate the therapeutic uses of
capsaicin as an alternative tool for some disorders. | |
| dc.description | 2023 | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.rights | restricted access | |
| dc.subject | Capsaicina | |
| dc.subject | Dor | |
| dc.subject | Pungência | |
| dc.subject | Canais de Cátion TRPV | |
| dc.subject | Canabinoide | |
| dc.subject | Capsaicin | |
| dc.subject | Pungency | |
| dc.subject | Vanilloid | |
| dc.subject | Cannabinoid | |
| dc.subject | TRPV1 | |
| dc.subject | Pain | |
| dc.subject | Canais de Cátion TRPV | |
| dc.subject | Agonistas de Receptores de Canabinoides | |
| dc.title | Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities | |
| dc.type | Article | |
