Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective

dc.creatorEl-Hani, Charbel Niño
dc.creatorBorges, Valeria de Matos
dc.creatorWanderley, João Luiz Mendes
dc.creatorBarcinski, Marcello André
dc.date2015-02-11T12:29:31Z
dc.date2015-02-11T12:29:31Z
dc.date2012
dc.date.accessioned2023-09-26T20:19:23Z
dc.date.available2023-09-26T20:19:23Z
dc.identifierEL-HANI, C. N. et al. Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective. Frontiers in Cellular and Infection Microbiology, v. 2, p. 1-6, 2012.
dc.identifier2235-2988
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9484
dc.identifier10.3389/fcimb.2012.00096
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854205
dc.descriptionApoptotic death and apoptotic mimicry are defined respectively as a non-accidental death and as the mimicking of an apoptotic-cell phenotype, usually by phosphatidylserine (PS) exposure. In the case of the murine infection by Leishmania spp, apoptotic death has been described in promastigotes and apoptotic mimicry in amastigotes. In both situations they are important events of the experimental murine infection by this parasite. In the present review we discuss what features we need to consider if we want to establish if a behavior shown by Leishmania is altruistic or not: does the behavior increases the fitness of organisms other than the one showing it? Does this behavior have a cost for the actor? If we manage to show that a given behavior is costly for the actor and beneficial for the recipient of the action, we will be able to establish it as altruistic. From this perspective, we can argue that apoptotic-like death and apoptotic mimicry are both altruistic with the latter representing a weaker altruistic behavior than the former.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers
dc.rightsopen access
dc.subjectLeishmania spp
dc.subjectApoptosis
dc.subjectApoptotic mimicry
dc.subjectEvolution
dc.subjectAltruism
dc.subjectunicellular parasites
dc.subjectApoptose
dc.subjectEvolução Biológica
dc.subjectLeishmania/fisiologia
dc.subjectAnimais
dc.subjectHumanos
dc.subjectLeishmania/patogenicidade
dc.subjectCamundongos
dc.titleApoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective
dc.typeArticle


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