Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection

dc.creatorOliveira, Gabriel Melo de
dc.creatorMasuda, Masako Oya
dc.creatorRocha, Nazaré N.
dc.creatorSchor, Nestor
dc.creatorHooper, Cléber S.
dc.creatorAraujo-Jorge, Tania C.
dc.creatorHenriques-Pons, Andréa
dc.date2018-09-23T15:33:23Z
dc.date2018-09-23T15:33:23Z
dc.date2009
dc.date.accessioned2023-09-26T20:19:08Z
dc.date.available2023-09-26T20:19:08Z
dc.identifierOLIVEIRA, Gabriel Melo de; et al. Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection. Mem Inst Oswaldo Cruz, v.104, n.8, p.1063-1071, Dec. 2009.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29000
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854109
dc.descriptionTrypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectmiocardite
dc.subjectlesão renal aguda
dc.subjectTrypanosoma cruzi
dc.subjectFas-L
dc.subjectmiocarditis
dc.subjectacute kidney injury
dc.titleAbsence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection
dc.typeArticle


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