Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region

dc.creatorOliveira, Rodrigo Cunha
dc.creatorGraf, Tiago
dc.creatorRego, Filipe Ferreira de Almeida
dc.creatorSilva, Gabriela Porto Santos Almeida
dc.creatorGiovanetti, Marta
dc.creatorCunha, Joana Paixão Monteiro
dc.date2021-11-25T18:45:41Z
dc.date2021-11-25T18:45:41Z
dc.date2021
dc.date.accessioned2023-09-26T20:18:58Z
dc.date.available2023-09-26T20:18:58Z
dc.identifierOLIVEIRA, Rodrigo Cunha et al. Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region. AIDS Research and Human Retroviruses, 2021.
dc.identifier0889-2229
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50067
dc.identifier10.1089/aid.2020.0308
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854043
dc.descriptionFundação de Amparo a` Pesquisa do Estado da Bahia (FAPESB) for the masters scholarship. M.G. thanks Fundação de Amparo a` Pesquisa do Estado do Rio de Janeiro (FAPERJ).
dc.descriptionThe subtype C accounts for >50% of HIV type 1 (HIV-1) infections worldwide and it is currently the predominant viral form in South Brazil. Subtype C has been reported in all Brazilian regions; however, the phylogenetic relationship among strains circulating in those regions still remains unclear. This study aimed to investigate the origin and dynamic dispersion of HIV-1 subtype C toward Northeast Brazil. Our phylogenetic analysis suggests that most subtype C strains circulating in Brazil (99%) are descendant from the main lineage whose entrance in the country was previously described in the 1970s. According to the literature, additional introductions of subtype C were reported in the country through the Southeast region and in this study we identified another entry event that occurred most likely through the North region. Furthermore, our analysis suggests that the spread of subtype C to Brazilian Northeastern states occurred through multiple independent introductions of the main lineage that originated in South Brazil between mid-1980s and late 1990s. Despite the observation of eventual new HIV-1 subtype C introductions, our results highlight the predominance of a single lineage of this subtype in Brazil and the importance of South region in its dissemination throughout the country.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMary Ann Liebert
dc.rightsopen access
dc.subjectHIV-1
dc.subjectInfecções
dc.subjectBrasil
dc.subjectNordeste
dc.subjectHIV-1
dc.subjectSubtype C
dc.subjectBrazil
dc.subjectNortheast
dc.titleDynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
dc.typeArticle


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